Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA073328-01
Application #
2011354
Study Section
Special Emphasis Panel (SRC (02))
Project Start
1996-09-30
Project End
1999-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Setchell, Kenneth D R; Clerici, Carlo; Lephart, Edwin D et al. (2005) S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 81:1072-9
Setchell, Kenneth D R; Brown, Nadine Maynard; Desai, Pankaj B et al. (2003) Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. J Nutr 133:1027-35
Setchell, Kenneth D R; Cole, Sidney J (2003) Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling. J Agric Food Chem 51:4146-55
Setchell, Kenneth D R; Brown, Nadine M; Lydeking-Olsen, Eva (2002) The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577-84
Setchell, Kenneth D R; Brown, Nadine M; Zimmer-Nechemias, Linda et al. (2002) Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 76:447-53
Scheiber, M D; Liu, J H; Subbiah, M T et al. (2001) Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 8:384-92
Setchell, K D (2000) Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. J Nutr 130:654S-5S
Lephart, E D; Thompson, J M; Setchell, K D et al. (2000) Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res 859:123-31
Weber, K S; Jacobson, N A; Setchell, K D et al. (1999) Brain aromatase and 5alpha-reductase, regulatory behaviors and testosterone levels in adult rats on phytoestrogen diets. Proc Soc Exp Biol Med 221:131-5