Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA074072-05
Application #
6696743
Study Section
Pathology B Study Section (PTHB)
Program Officer
Perry, Mary Ellen
Project Start
1998-07-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
5
Fiscal Year
2004
Total Cost
$227,250
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
052780918
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Kozloski, Goldi A; Carraway, Coralie A Carothers; Carraway, Kermit L (2010) Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity. J Cell Physiol 224:649-57
Theodoropoulos, George; Carraway, Coralie A Carothers; Carraway, Kermit L (2009) MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury. J Cell Biochem 107:112-22
Theodoropoulos, George; Carraway, Kermit L (2007) Molecular signaling in the regulation of mucins. J Cell Biochem 102:1103-16
Ramsauer, Victoria P; Pino, Vanessa; Farooq, Amjad et al. (2006) Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell 17:2931-41
Pino, Vanessa; Ramsauer, Victoria P; Salas, Pedro et al. (2006) Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells: role in reversal of contact inhibition. J Biol Chem 281:29411-20
Soto, Pedro; Zhang, Jin; Carraway, Kermit L (2006) Enzymatic cleavage as a processing step in the maturation of Muc4/sialomucin complex. J Cell Biochem 97:1267-74
Price-Schiavi, Shari A; Andrechek, Eran; Idris, Nebila et al. (2005) Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol 203:44-53
Nagy, Peter; Friedlander, Elza; Tanner, Minna et al. (2005) Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 65:473-82
Carraway, Kermit L; Ramsauer, Victoria P; Carraway, Coralie A Carothers (2005) Glycoprotein contributions to mammary gland and mammary tumor structure and function: roles of adherens junctions, ErbBs and membrane MUCs. J Cell Biochem 96:914-26
Ramsauer, Victoria P; Carraway, Coralie A Carothers; Salas, Pedro J I et al. (2003) Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem 278:30142-7

Showing the most recent 10 out of 22 publications