Abstract

The aims of this proposal are designed to provide a basic understanding of (1) the cellular basis of gammaHV68 latency; (2) the role of the immune system in regulating latency; (3) the viral gene products expressed during latency; and (4) the role of latency-associated gene products in latency and tumorigenesis.
Aim 1. Characterization of gamma HV68 latency in immunocompetent and B cekk deficient mice.
Aim 2. Regulation of gamma HV68 latency and gamma HV68-associated tumor developed by the immune system.
Aim 3. Characterization of gamma HV 68 latency and tumor associated gene expression.
Aim 4. Generation and analysis of gamma HV68 mutants in latency and tumor-associated genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA074730-05
Application #
6513084
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Program Officer
Read-Connole, Elizabeth Lee
Project Start
1998-05-01
Project End
2003-09-29
Budget Start
2002-03-22
Budget End
2003-09-29
Support Year
5
Fiscal Year
2002
Total Cost
$363,851
Indirect Cost

  Institution

Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Virgin, Herbert W; Todd, John A (2011) Metagenomics and personalized medicine. Cell 147:44-56
White, Douglas W; Keppel, Catherine R; Schneider, Stephanie E et al. (2010) Latent herpesvirus infection arms NK cells. Blood 115:4377-83
Tarakanova, Vera L; Molleston, Jerome M; Goodwin, Megan et al. (2010) MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. Virology 396:323-8
Virgin, Herbert W; Levine, Beth (2009) Autophagy genes in immunity. Nat Immunol 10:461-70
Stephenson, Linda M; Miller, Brian C; Ng, Aylwin et al. (2009) Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 5:625-35
Tarakanova, Vera L; Leung-Pineda, Van; Hwang, Seungmin et al. (2007) Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe 1:275-86
Braaten, Douglas C; McClellan, James Scott; Messaoudi, Ilhem et al. (2006) Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells. PLoS Pathog 2:e37
Talloczy, Zsolt; Virgin 4th, Herbert W; Levine, Beth (2006) PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy 2:24-9
McClellan, Kelly B; Gangappa, Shivaprakash; Speck, Samuel H et al. (2006) Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses. PLoS Pathog 2:e58
Braaten, Douglas C; Sparks-Thissen, Rebecca L; Kreher, Scott et al. (2005) An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection. J Virol 79:2573-83

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