Abstract

The investigator proposes to study SIV-associated lymphomas in a rhesus macaque model for AIDS. The genetic alterations in these lymphomas, the role of rhEBV (an EBV-like virus), and perturbation of various cytokines will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA074731-01
Application #
2331070
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1997-05-01
Project End
2000-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Tulane University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

Saba, Nakhle S; Levy, Laura S (2012) Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells. J Investig Med 60:29-38
Saba, Nakhle S; Levy, Laura S (2011) Apoptotic induction in B-cell acute lymphoblastic leukemia cell lines treated with a protein kinase C? inhibitor. Leuk Lymphoma 52:877-86
Ruff, Kristin R; Puetter, Adriane; Levy, Laura S (2007) Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-beta1 and IL-6. BMC Cancer 7:35
Fortgang, Ilana S; Srivastav, Sudesh K; Baskin, Gary B et al. (2004) Retrospective analysis of clinical and laboratory factors associated with lymphoma in simian AIDS. Leuk Lymphoma 45:161-9
Ruff, K; Baskin, G B; Simpson, L et al. (2003) Rhesus rhadinovirus infection in healthy and SIV-infected macaques at Tulane National Primate Research Center. J Med Primatol 32:1-6
Fortgang, I S; Rege, T; Baskin, G B et al. (2001) Variation in simian immunodeficiency virus env V1 region in simian AIDS-associated lymphoma. AIDS Res Hum Retroviruses 17:459-65
Habis, A; Baskin, G; Simpson, L et al. (2000) Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. AIDS Res Hum Retroviruses 16:163-71
Fortgang, I S; Didier, P J; Levy, L S (2000) B-cell leukemia in a rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus. Leuk Lymphoma 37:657-62
Habis, A; Baskin, G B; Murphey-Corb, M et al. (1999) Simian AIDS-associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin's lymphoma. AIDS Res Hum Retroviruses 15:1389-98