Two structurally unique compounds, CP-263,114 and CP-225,917, were recently isolated from an unidentified fungus while screening for squalene synthase inhibitors. These natural products were found to inhibit ras farnesyl transferase. One objective of this grant application is to develop a practical and efficient total synthesis of CP-263,114 and CP-225,917 which will allow the production of modified versions of these inhibitors for evaluation against ras farnesyl transferase and squalene synthase.
|Sulikowski, Gary A; Agnelli, Fabio; Spencer, Paul et al. (2002) Studies on the biosynthesis of phomoidride B (CP-263,114): evidence for a decarboxylative homodimerization pathway. Org Lett 4:1447-50|
|Sulikowski, Gary A; Liu, Weidong; Agnelli, Fabio et al. (2002) Progress toward a biomimetic synthesis of phomoidride B. Org Lett 4:1451-4|
|Spencer, P; Agnelli, F; Sulikowski, G A (2001) Investigations into the production and interconversion of phomoidrides A-D. Org Lett 3:1443-5|
|Sulikowski, G A; Agnelli, F; Corbett, R M (2000) Investigations into a biomimetic approach toward CP-225,917 and CP-263,114. J Org Chem 65:337-42|