Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA075577-05A1S1
Application #
6764631
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Rosenfeld, Bobby
Project Start
1998-04-01
Project End
2006-08-31
Budget Start
2003-05-01
Budget End
2003-08-31
Support Year
5
Fiscal Year
2003
Total Cost
$20,642
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Biochemistry
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Bateman, T David; Joshi, Aarti L; Moon, Kwangyul et al. (2009) Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans. Bioorg Med Chem Lett 19:6898-901
Upreti, Meenakshi; Chu, Rong; Galitovskaya, Elena et al. (2008) Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Ther 7:2224-32
Kolomeichuk, Sergey N; Terrano, David T; Lyle, Christopher S et al. (2008) Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. FEBS J 275:1889-99
Duan, Lingling; Sterba, Kristen; Kolomeichuk, Sergey et al. (2007) Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol 73:481-90
Upreti, Meenakshi; Lyle, Christopher S; Skaug, Brian et al. (2006) Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. J Biol Chem 281:15941-50
Zharov, Vladimir P; Galitovskiy, Valentin; Lyle, Christopher S et al. (2006) Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drug. J Biomed Opt 11:064034
Kurten, Richard C; Chowdhury, Parag; Sanders Jr, Ronald C et al. (2005) Coordinating epidermal growth factor-induced motility promotes efficient wound closure. Am J Physiol Cell Physiol 288:C109-21
Obey, Toria B; Lyle, Christopher S; Chambers, Timothy C (2005) Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine. Biochem Biophys Res Commun 335:1179-84
Du, Lihua; Lyle, Christopher S; Chambers, Timothy C (2005) Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction. Oncogene 24:107-17
Bene, Anca; Kurten, Richard C; Chambers, Timothy C (2004) Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic Acids Res 32:e142

Showing the most recent 10 out of 20 publications