The proposed research will investigate the hypothesis that green tea catechins are versatile antioxidants capable of preventing oxidative damage by diverse oxidants in biological systems. The investigators will 1) identify products of green tea catechins (EGCG, EGC, and ECG) reaction with peroxyl radicals, hydroxyl radicals, peroxynitrite, and singlet oxygen in chemically defined model systems; 2) develop sensitive assays for specific reaction products indicative of the antioxidant reactions; 3) characterize antioxidant reactions of the catechins in mouse skin treated with tumor promoters and UVB in vivo.
| Liebler, D C; Valcic, S; Arora, A et al. (2001) Antioxidant reactions of green tea catechins and soy isoflavones. Adv Exp Med Biol 500:191-7 |
| Valcic, S; Burr, J A; Timmermann, B N et al. (2000) Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals. Chem Res Toxicol 13:801-10 |
| Arora, A; Valcic, S; Cornejo, S et al. (2000) Reactions of Genistein with alkylperoxyl radicals. Chem Res Toxicol 13:638-45 |
| Valcic, S; Muders, A; Jacobsen, N E et al. (1999) Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals. Chem Res Toxicol 12:382-6 |
