Dr. Thomas will build on her exciting preparation of pax-/- mice to investigate the role of this intriguing adapter protein in development, interactions of cells with the extracellular matrix, and as a target of transforming oncogenes such as src or abl.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA075621-05
Application #
6376537
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Ault, Grace S
Project Start
1997-08-15
Project End
2003-07-31
Budget Start
2001-08-24
Budget End
2003-07-31
Support Year
5
Fiscal Year
2001
Total Cost
$263,753
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Yang, Wentian; Klaman, Lori D; Chen, Binbin et al. (2006) An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell 10:317-27
Kowalski, Jennifer R; Egile, Coumaran; Gil, Susana et al. (2005) Cortactin regulates cell migration through activation of N-WASP. J Cell Sci 118:79-87
Chen, Guang-Chao; Turano, Brian; Ruest, Paul J et al. (2005) Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development. Mol Cell Biol 25:979-87
Brachmann, Saskia M; Yballe, Claudine M; Innocenti, Metello et al. (2005) Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol 25:2593-606
Hagel, Margit; George, Elizabeth L; Kim, Ann et al. (2002) The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 22:901-15
Young, B A; Taooka, Y; Liu, S et al. (2001) The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell 12:3214-25
Oh, E S; Gu, H; Saxton, T M et al. (1999) Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol 19:3205-15
Thomas, S M; Hagel, M; Turner, C E (1999) Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin. J Cell Sci 112 ( Pt 2):181-90
Ishida, M; Ishida, T; Thomas, S M et al. (1998) Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ Res 82:7-12