Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA076348-07
Application #
6707515
Study Section
Chemical Pathology Study Section (CPA)
Program Officer
Poland, Alan P
Project Start
1998-09-01
Project End
2007-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
7
Fiscal Year
2004
Total Cost
$279,571
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Xiao, Hui; Rawal, Malika; Hahm, Eun-Ryeong et al. (2007) Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line. Cell Cycle 6:2826-34
Xiao, Hui; Singh, Shivendra V (2007) p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells. Cell Cycle 6:1753-61
Srivastava, Sanjay K; Bansal, Pallavi; Oguri, Tetsuya et al. (2007) Cell division cycle 25B phosphatase is essential for benzo(a)pyrene-7,8-Diol-9,10-epoxide induced neoplastic transformation. Cancer Res 67:9150-7
Xiao, Dong; Herman-Antosiewicz, Anna; Antosiewicz, Jedrzej et al. (2005) Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C. Oncogene 24:6256-68
Xiao, Dong; Choi, Sunga; Lee, Yong J et al. (2005) Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells. Mol Carcinog 43:130-40
Singh, Shivendra V; Srivastava, Sanjay K; Choi, Sunga et al. (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 280:19911-24
Herman-Antosiewicz, Anna; Singh, Shivendra V (2005) Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells. J Biol Chem 280:28519-28
Xiao, Dong; Zeng, Yan; Choi, Sunga et al. (2005) Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax. Clin Cancer Res 11:2670-9
Choi, Sunga; Singh, Shivendra V (2005) Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. Cancer Res 65:2035-43
Sharma, Rajendra; Brown, David; Awasthi, Sanjay et al. (2004) Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem 271:1690-701

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