Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA077267-02
Application #
6124471
Study Section
Special Emphasis Panel (ZRG3-MEDB (02))
Program Officer
Mohla, Suresh
Project Start
1998-12-15
Project End
2002-11-30
Budget Start
1999-12-01
Budget End
2000-11-30
Support Year
2
Fiscal Year
2000
Total Cost
$205,767
Indirect Cost
Name
Dartmouth College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Brinckerhoff, Constance E (2017) Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire? J Cell Physiol 232:2674-2678
Brinckerhoff, Constance E (2016) What are the therapeutic implications of increased collagen expression in melanoma cells treated with vemurafenib? Melanoma Manag 3:5-8
Jenkins, Molly H; Croteau, Walburga; Mullins, David W et al. (2015) The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells. Matrix Biol 48:66-77
Whipple, Chery A (2015) Tumor talk: understanding the conversation between the tumor and its microenvironment. Cancer Cell Microenviron 2:e773
Jenkins, Molly H; Steinberg, Shannon M; Alexander, Matthew P et al. (2014) Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032. Pigment Cell Melanoma Res 27:495-501
Whipple, C A; Brinckerhoff, C E (2014) BRAF(V600E) melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity. Br J Cancer 111:1625-33
Croteau, Walburga; Jenkins, Molly H; Ye, Siying et al. (2013) Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma. J Cell Physiol 228:773-80
Schmucker, Adam C; Wright, Jason B; Cole, Michael D et al. (2012) Distal interleukin-1? (IL-1?) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression. J Biol Chem 287:1189-97
Zhou, Jing; Brinckerhoff, Constance; Lubert, Susan et al. (2011) Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. Cancer Invest 29:599-607
Eck, Sarah M; Côté, Anik L; Winkelman, William D et al. (2009) CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells. Mol Cancer Res 7:1033-44

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