Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA077545-03
Application #
6376713
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1999-07-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2003-06-30
Support Year
3
Fiscal Year
2001
Total Cost
$299,961
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Nagai, Shinjiro; Takenaka, Kazumasa; Nachagari, Deepa et al. (2011) Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res 71:1781-91
Krishnamurthy, Partha; Xie, Tao; Schuetz, John D (2007) The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther 114:345-58
Takenaka, Kazumasa; Morgan, Jessica A; Scheffer, George L et al. (2007) Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res 67:6965-72
Krishnamurthy, P; Schuetz, J D (2006) Role of ABCG2/BCRP in biology and medicine. Annu Rev Pharmacol Toxicol 46:381-410
Krishnamurthy, Partha; Schuetz, John D (2005) The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival. Biometals 18:349-58
Masson, David; Lagrost, Laurent; Athias, Anne et al. (2005) Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile. Arterioscler Thromb Vasc Biol 25:2164-9
Krishnamurthy, Partha; Ross, Douglas D; Nakanishi, Takeo et al. (2004) The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279:24218-25
Assem, Mahfoud; Schuetz, Erin G; Leggas, Markos et al. (2004) Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 279:22250-7
Doyle, L Austin; Ross, Douglas D (2003) Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22:7340-58
Nakanishi, Takeo; Doyle, L Austin; Hassel, Bret et al. (2003) Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Mol Pharmacol 64:1452-62

Showing the most recent 10 out of 19 publications