Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA077632-03
Application #
6329037
Study Section
Medical Biochemistry Study Section (MEDB)
Program Officer
Forry-Schaudies, Suzanne L
Project Start
1998-12-09
Project End
2001-11-30
Budget Start
2000-12-06
Budget End
2001-11-30
Support Year
3
Fiscal Year
2001
Total Cost
$225,901
Indirect Cost
Name
John Wayne Cancer Institute
Department
Type
DUNS #
556074458
City
Santa Monica
State
CA
Country
United States
Zip Code
90404
Liu, Yong-Yu; Cabot, Myles C (2004) Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-alpha-induced apoptosis. Methods Mol Biol 249:177-92
Litvak, David A; Bilchik, Anton J; Cabot, Myles C (2003) Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. J Gastrointest Surg 7:140-8; discussion 148
Wang, Hongtao; Giuliano, Armando E; Cabot, Myles C (2002) Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells. Mol Cancer Ther 1:719-26
Senchenkov, A; Litvak, D A; Cabot, M C (2001) Targeting ceramide metabolism--a strategy for overcoming drug resistance. J Natl Cancer Inst 93:347-57
Liu, Y Y; Han, T Y; Giuliano, A E et al. (2001) Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 15:719-30
Senchenkov, A; Han, T Y; Wang, H et al. (2001) Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF. Blood 98:1927-34
Wang, H; Maurer, B J; Reynolds, C P et al. (2001) N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res 61:5102-5
Charles, A G; Han, T Y; Liu, Y Y et al. (2001) Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother Pharmacol 47:444-50
Goulding, C W; Giuliano, A E; Cabot, M C (2000) SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein. Cancer Lett 149:143-51
Liu, Y Y; Han, T Y; Giuliano, A E et al. (2000) Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J Biol Chem 275:7138-43

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