Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA077764-01A1
Application #
2799016
Study Section
Special Emphasis Panel (ZRG2-ET-1 (04))
Program Officer
Yovandich, Jason L
Project Start
1999-02-10
Project End
2002-01-31
Budget Start
1999-02-10
Budget End
2000-01-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Jahrsdorfer, Bernd; Blackwell, Sue E; Wooldridge, James E et al. (2006) B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood 108:2712-9
Jahrsdorfer, Bernd; Wooldridge, James E; Blackwell, Sue E et al. (2005) Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells. J Leukoc Biol 77:378-87
Jahrsdorfer, B; Wooldridge, J E; Blackwell, S E et al. (2005) Good prognosis cytogenetics in B-cell chronic lymphocytic leukemia is associated in vitro with low susceptibility to apoptosis and enhanced immunogenicity. Leukemia 19:759-66
Jahrsdorfer, Bernd; Blackwell, Sue E; Weiner, George J (2005) Phosphorothyoate oligodeoxynucleotides block nonspecific binding of Cy5 conjugates to monocytes. J Immunol Methods 297:259-63
Jahrsdorfer, Bernd; Blackwell, Sue E; Wooldridge, James E et al. (2005) Serum alters the uptake and biologic activity of CpG oligodeoxynucleotides in B cell chronic lymphocytic leukemia. Oligonucleotides 15:51-9
van Ojik, Heidi H; Bevaart, Lisette; Dahle, Christopher E et al. (2003) CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations. Cancer Res 63:5595-600
Jahrsdorfer, Bernd; Weiner, George J (2003) Immunostimulatory CpG oligodeoxynucleotides and antibody therapy of cancer. Semin Oncol 30:476-82
Jahrsdorfer, B; Hartmann, G; Racila, E et al. (2001) CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J Leukoc Biol 69:81-8
Ballas, Z K; Krieg, A M; Warren, T et al. (2001) Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J Immunol 167:4878-86
Weiner, G J (2000) The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J Leukoc Biol 68:455-63