Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA079804-05
Application #
6633317
Study Section
Pathology B Study Section (PTHB)
Program Officer
Blair, Donald G
Project Start
1999-07-01
Project End
2006-04-30
Budget Start
2003-05-01
Budget End
2006-04-30
Support Year
5
Fiscal Year
2003
Total Cost
$273,087
Indirect Cost
Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Walsh, Erica M; Niu, MengMeng; Bergholz, Johann et al. (2015) Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun 461:293-9
Tong, Y; Ying, H; Liu, R et al. (2015) Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. Cell Death Dis 6:e1640
Wu, J; Liang, S; Bergholz, J et al. (2014) ?Np63? activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis 5:e1280
Tran, Duc; Bergholz, Johann; Zhang, Haibo et al. (2014) Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell 13:669-78
Bergholz, J; Zhang, Y; Wu, J et al. (2014) ?Np63? regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene 33:212-24
Du, Wei; Yi, Yong; Zhang, Haibo et al. (2013) Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS One 8:e63179
Wu, Junfeng; Bergholz, Johann; Lu, Jinin et al. (2010) TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem 109:702-10
Du, Wei; Wu, Junfeng; Walsh, Erica M et al. (2009) Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3. J Biol Chem 284:26315-21
Qiu, W; Wu, J; Walsh, E M et al. (2008) Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene 27:4034-43
Murray, Stephen A; Yang, Shi; Demicco, Elizabeth et al. (2005) Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem 95:875-84

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