Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA079903-04
Application #
6513433
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Woodhouse, Elizabeth
Project Start
1999-08-01
Project End
2004-04-30
Budget Start
2002-06-01
Budget End
2004-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$200,600
Indirect Cost
Name
University of Maryland Baltimore
Department
Dentistry
Type
Schools of Dentistry
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Costello, Leslie C; Franklin, Renty B (2017) Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas. Expert Opin Ther Targets 21:51-66
Franklin, Renty B; Zou, Jing; Zheng, Yao et al. (2016) Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer. Int J Cancer Clin Res 3:
Costello, Leslie C; Franklin, Renty B (2016) A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Arch Biochem Biophys 611:100-112
Costello, Leslie C; Zou, Jing; Franklin, Renty B (2016) In situ clinical evidence that zinc levels are decreased in breast invasive ductal carcinoma. Cancer Causes Control 27:729-35
Costello, Leslie C; Franklin, Renty B; Zou, Jing et al. (2015) Evidence that Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore (Clioquinol) Approach. Chemotherapy (Los Angel) 4:
Costello, Leslie C; Franklin, Renty B (2014) The status of zinc in the development of hepatocellular cancer: an important, but neglected, clinically established relationship. Cancer Biol Ther 15:353-60
Franklin, Renty B; Zou, Jing; Costello, Leslie C (2014) The cytotoxic role of RREB1, ZIP3 zinc transporter, and zinc in human pancreatic adenocarcinoma. Cancer Biol Ther 15:1431-7
Costello, Leslie C; Franklin, Renty B (2013) A Review of the Current Status and Concept of the Emerging Implications of Zinc and Zinc Transporters in the Development of Pancreatic Cancer. Pancreat Disord Ther Suppl 4:
Costello, Leslie C; Franklin, Renty B (2013) A review of the important central role of altered citrate metabolism during the process of stem cell differentiation. J Regen Med Tissue Eng 2:
Costello, Leslie C; Zou, Jing; Desouki, Mohamed Mokhtar et al. (2012) Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma. J Gastrointest Cancer 43:570-8

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