Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA080130-04
Application #
6475840
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1998-12-02
Project End
2004-11-30
Budget Start
2001-12-10
Budget End
2004-11-30
Support Year
4
Fiscal Year
2002
Total Cost
$217,501
Indirect Cost
Name
University of Arizona
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Morse, David L; Carroll, Danielle; Day, Sam et al. (2009) Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. NMR Biomed 22:114-27
Morse, David L; Galons, Jean-Philippe; Payne, Claire M et al. (2007) MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms. NMR Biomed 20:602-14
Morse, David L; Raghunand, Natarajan; Sadarangani, Pooja et al. (2007) Response of choline metabolites to docetaxel therapy is quantified in vivo by localized (31)P MRS of human breast cancer xenografts and in vitro by high-resolution (31)P NMR spectroscopy of cell extracts. Magn Reson Med 58:270-80
Morse, David L; Carroll, Danielle; Weberg, Lyndon et al. (2005) Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem 342:69-77
Tome, Margaret E; Lutz, Norbert W; Briehl, Margaret M (2004) Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance. Biochim Biophys Acta 1693:57-72
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Lutz, Norbert W; Tome, Margaret E; Cozzone, Patrick J (2003) Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-gamma/TNF-alpha in HT-29 cells. FEBS Lett 544:123-8
Lutz, N W; Tome, M E; Aiken, N R et al. (2002) Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone-induced apoptosis. A 31P NMR spectroscopic study of cell extracts. NMR Biomed 15:356-66