Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA080318-05
Application #
6624689
Study Section
Special Emphasis Panel (ZRG2-MEP (03))
Program Officer
Mohla, Suresh
Project Start
1998-12-15
Project End
2004-11-30
Budget Start
2002-12-01
Budget End
2004-11-30
Support Year
5
Fiscal Year
2003
Total Cost
$256,352
Indirect Cost
Name
University of Iowa
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Seftor, Richard E B; Hess, Angela R; Seftor, Elisabeth A et al. (2012) Tumor cell vasculogenic mimicry: from controversy to therapeutic promise. Am J Pathol 181:1115-25
Demou, Zoe N; Hendrix, Mary J C (2008) Microgenomics profile the endogenous angiogenic phenotype in subpopulations of aggressive melanoma. J Cell Biochem 105:562-73
Hess, Angela R; Margaryan, Naira V; Seftor, Elisabeth A et al. (2007) Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors. Dev Dyn 236:3283-96
Topczewska, Jolanta M; Postovit, Lynne-Marie; Margaryan, Naira V et al. (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925-32
Seftor, Elisabeth A; Meltzer, P S; Kirschmann, D A et al. (2006) The epigenetic reprogramming of poorly aggressive melanoma cells by a metastatic microenvironment. J Cell Mol Med 10:174-96
Hess, Angela R; Hendrix, Mary J C (2006) Focal adhesion kinase signaling and the aggressive melanoma phenotype. Cell Cycle 5:478-80
Hess, Angela R; Seftor, Elisabeth A; Gruman, Lynn M et al. (2006) VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry. Cancer Biol Ther 5:228-33
Hess, Angela R; Postovit, Lynne-Marie; Margaryan, Naira V et al. (2005) Focal adhesion kinase promotes the aggressive melanoma phenotype. Cancer Res 65:9851-60
Nickoloff, Brian J; Hendrix, Mary J C; Pollock, Pamela M et al. (2005) Notch and NOXA-related pathways in melanoma cells. J Investig Dermatol Symp Proc 10:95-104
Qin, Jian-Zhong; Ziffra, Jeffrey; Stennett, Lawrence et al. (2005) Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res 65:6282-93

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