Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA082171-01
Application #
2881543
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Freeman, Colette S
Project Start
1999-07-01
Project End
2004-04-30
Budget Start
1999-07-01
Budget End
2000-04-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Princeton University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544

  Publications

Lin, Xia; Duan, Xueyan; Liang, Yao-Yun et al. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 125:915-28
Shi, Yigong; Massague, Joan (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-700
Chai, Jijie; Wu, Jia-Wei; Yan, Nieng et al. (2003) Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J Biol Chem 278:20327-31
Wu, Jia Wei; Krawitz, Ariel R; Chai, Jijie et al. (2002) Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell 111:357-67
Wu, J W; Hu, M; Chai, J et al. (2001) Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Mol Cell 8:1277-89
Wu, J W; Fairman, R; Penry, J et al. (2001) Formation of a stable heterodimer between Smad2 and Smad4. J Biol Chem 276:20688-94