Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA082440-02
Application #
6174216
Study Section
Special Emphasis Panel (ZRG1-PTHB (01))
Program Officer
Ault, Grace S
Project Start
1999-08-01
Project End
2003-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
2
Fiscal Year
2000
Total Cost
$168,455
Indirect Cost
Name
Medical University of South Carolina
Department
Pathology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Sui, Meihua; Fan, Weimin (2005) Combination of gamma-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis. Int J Radiat Oncol Biol Phys 61:1151-8
Zhu, Xueming; Sui, Meihua; Fan, Weimin (2005) In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Anticancer Res 25:1953-62
Huang, Yi; Fang, Yong; Wu, Jinmin et al. (2004) Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells. Mol Cancer Ther 3:271-7
Sui, Meihua; Dziadyk, Jennifer M; Zhu, Xueming et al. (2004) Cell cycle-dependent antagonistic interactions between paclitaxel and gamma-radiation in combination therapy. Clin Cancer Res 10:4848-57
Fan, Weimin; Sui, Meihua; Huang, Yi (2004) Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact. Curr Med Chem 11:403-11
Dziadyk, Jennifer M; Sui, Meihua; Zhu, Xueming et al. (2004) Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res 24:27-36
Huang, Yi; Fan, Weimin (2002) IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. Mol Pharmacol 61:105-13
Johnson, Korey R; Fan, Weimin (2002) Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 22:3197-204
Huang, Yi; Fang, Yong; Dziadyk, Jennifer M et al. (2002) The possible correlation between activation of NF-kappaB/IkappaB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis. Oncol Res 13:113-22
Fu, L W; Deng, Z A; Pan, Q C et al. (2001) Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res 21:2273-80

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