Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA082673-04
Application #
6514131
Study Section
Physical Biochemistry Study Section (PB)
Program Officer
Knowlton, John R
Project Start
1999-07-01
Project End
2003-10-31
Budget Start
2002-05-10
Budget End
2003-10-31
Support Year
4
Fiscal Year
2002
Total Cost
$232,761
Indirect Cost
Name
Purdue University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Zabell, Adam P R; Schroff Jr, Alfred D; Bain, Bornadata Evans et al. (2006) Crystal structure of the human B-form low molecular weight phosphotyrosyl phosphatase at 1.6-A resolution. J Biol Chem 281:6520-7
Gustafson, Christin L T; Stauffacher, Cynthia V; Hallenga, Klaas et al. (2005) Solution structure of the low-molecular-weight protein tyrosine phosphatase from Tritrichomonas foetus reveals a flexible phosphate binding loop. Protein Sci 14:2515-25
Laurence, Jennifer S; Hallenga, Klaas; Stauffacher, Cynthia V (2004) 1H, 15N, 13C resonance assignments of the human protein tyrosine phosphatase PRL-1. J Biomol NMR 29:417-8
Hedl, Matija; Tabernero, Lydia; Stauffacher, Cynthia V et al. (2004) Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases. J Bacteriol 186:1927-32
Zabell, Adam P R; Corden, Steven; Helquist, Paul et al. (2004) Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase. Bioorg Med Chem 12:1867-80
Wang, S; Stauffacher, C V; Van Etten, R L (2000) Structural and mechanistic basis for the activation of a low-molecular weight protein tyrosine phosphatase by adenine. Biochemistry 39:1234-42
Wang, S; Tabernero, L; Zhang, M et al. (2000) Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate. Biochemistry 39:1903-14