Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA083070-11
Application #
6174313
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Finerty, John F
Project Start
1999-08-05
Project End
2005-05-31
Budget Start
2000-06-01
Budget End
2002-05-31
Support Year
11
Fiscal Year
2000
Total Cost
$276,593
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Curran, Shane A; Shyer, Justin A; St Angelo, Erin T et al. (2017) Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade. Cancer Immunol Res 5:52-60
Curran, Shane A; Romano, Emanuela; Kennedy, Michael G et al. (2014) Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells. Cancer Immunol Res 2:1000-10
Chung, David J; Romano, Emanuela; Pronschinske, Katherine B et al. (2013) Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy. J Transl Med 11:166
Romano, Emanuela; Cotari, Jesse W; Barreira da Silva, Rosa et al. (2012) Human Langerhans cells use an IL-15R-?/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1. Blood 119:5182-90
Betts, Brian C; St Angelo, Erin T; Kennedy, Michael et al. (2011) Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses. Blood 118:5340-3
Betts, Brian C; Abdel-Wahab, Omar; Curran, Shane A et al. (2011) Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen. Blood 118:5330-9
Romano, Emanuela; Rossi, Marco; Ratzinger, Gudrun et al. (2011) Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo. Clin Cancer Res 17:1984-97
Bamboat, Zubin M; Stableford, Jennifer A; Plitas, George et al. (2009) Human liver dendritic cells promote T cell hyporesponsiveness. J Immunol 182:1901-11
Strowig, Till; Gurer, Cagan; Ploss, Alexander et al. (2009) Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 206:1423-34
Chung, David J; Rossi, Marco; Romano, Emanuela et al. (2009) Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Blood 114:555-63

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