Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA084212-03
Application #
6497950
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Spalholz, Barbara A
Project Start
2000-02-01
Project End
2005-01-31
Budget Start
2002-02-01
Budget End
2003-01-31
Support Year
3
Fiscal Year
2002
Total Cost
$167,853
Indirect Cost

  Institution

Name
Cleveland State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44115

  Publications

Freer-Prokop, Margot; O'Flaherty, John; Ross, Jason A et al. (2009) Non-canonical role for the TRAIL receptor DR5/FADD/caspase pathway in the regulation of MyoD expression and skeletal myoblast differentiation. Differentiation 78:205-12
Zhou, Yan; Weyman, Crystal M; Liu, Hongli et al. (2008) IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression. J Interferon Cytokine Res 28:65-72
Koo, Bon-Hun; Goff, Carine Le; Jungers, Katherine A et al. (2007) ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol 26:431-41
Shaltouki, Atossa; Freer, Margot; Mei, Yu et al. (2007) Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis 12:2143-54
O'Flaherty, J; Mei, Y; Freer, M et al. (2006) Signaling through the TRAIL receptor DR5/FADD pathway plays a role in the apoptosis associated with skeletal myoblast differentiation. Apoptosis 11:2103-13
Karasarides, M; Dee, K; Schulman, D et al. (2006) Active Ras-induced effects on skeletal myoblast differentiation and apoptosis are independent of constitutive PI3-kinase activity. Cell Biol Int 30:308-18
Dee, Keith; DeChant, Anne; Weyman, Crystal M (2003) Differential signaling through NFkappaB does not ameliorate skeletal myoblast apoptosis during differentiation. FEBS Lett 545:246-52
DeChant, Anne K; Dee, Keith; Weyman, Crystal M (2002) Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation. Oncogene 21:5268-79
Dee, K; Freer, M; Mei, Y et al. (2002) Apoptosis coincident with the differentiation of skeletal myoblasts is delayed by caspase 3 inhibition and abrogated by MEK-independent constitutive Ras signaling. Cell Death Differ 9:209-18