Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA085463-01
Application #
6085912
Study Section
Special Emphasis Panel (ZRG1-SSS-1 (03))
Program Officer
Mohla, Suresh
Project Start
2000-06-01
Project End
2005-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
1
Fiscal Year
2000
Total Cost
$268,136
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zeller, Jorg; Turbiak, Anjanette J; Powelson, Ian A et al. (2013) Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of *-catenin/TCF transcription. Bioorg Med Chem Lett 23:5814-20
Zhai, Y; Iura, A; Yeasmin, S et al. (2011) MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma. Oncogene 30:4152-62
Bommer, Guido T; Feng, Ying; Iura, Ayaka et al. (2010) IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem 285:1928-38
Akyol, Aytekin; Hinoi, Takao; Feng, Ying et al. (2008) Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods 5:231-3
Hinoi, Takao; Akyol, Aytekin; Theisen, Brian K et al. (2007) Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res 67:9721-30
Bommer, Guido T; Gerin, Isabelle; Feng, Ying et al. (2007) p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17:1298-307
Wu, Rong; Hendrix-Lucas, Neali; Kuick, Rork et al. (2007) Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell 11:321-33
Feng, Ying; Bommer, Guido T; Zhai, Yali et al. (2007) Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Cancer Res 67:482-91
Winer, Ira S; Bommer, Guido T; Gonik, Nathan et al. (2006) Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281:26181-7
Hendrix, Neali D; Wu, Rong; Kuick, Rork et al. (2006) Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 66:1354-62

Showing the most recent 10 out of 17 publications