Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085577-02
Application #
6692985
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Fu, Yali
Project Start
2003-01-01
Project End
2004-09-30
Budget Start
2004-01-01
Budget End
2004-09-30
Support Year
2
Fiscal Year
2004
Total Cost
$302,600
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
073724262
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Zhou, Qingyu; Guo, Ping; Gallo, James M (2008) Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 14:1540-9
Wang, Shining; Guo, Ping; Wang, Xiaomin et al. (2008) Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models. Mol Cancer Ther 7:407-17
Guo, Ping; Wang, Xiaomin; Liu, Liansheng et al. (2007) Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 43:1789-95
Kruh, Gary D; Belinsky, Martin G; Gallo, James M et al. (2007) Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev 26:5-14
Belinsky, Martin G; Guo, Ping; Lee, Kun et al. (2007) Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res 67:262-8
Zhou, Qingyu; Guo, Ping; Kruh, Gary D et al. (2007) Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition. Clin Cancer Res 13:4271-9
Zhou, Qingyu; Guo, Ping; Wang, Xiaomin et al. (2007) Preclinical pharmacokinetic and pharmacodynamic evaluation of metronomic and conventional temozolomide dosing regimens. J Pharmacol Exp Ther 321:265-75
Mitsuuchi, Y; Powell, D R; Gallo, J M (2006) Adenoviral modification of mouse brain derived endothelial cells, bEnd3, to induce apoptosis by vascular endothelial growth factor. Oncogene 25:954-8