Cigarette smoking is an enormous public health problem. Although our understanding of the consequences of smoking is relatively advanced, our knowledge of the determinants of smoking cessation- and its frequent concomitant relapse-is far less complete. Enduring smoking cessation remains an elusive goal for most heavy smokers. The extraordinary addictiveness of nicotine is certainly a prominent cause of these difficulties, but cannot of itself explain the marked inter-individual differences in smoking cessation and relapse. The overarching goal of this proposal is to delineate etiological factors involved in smoking cessation and relapse. To accomplish this aim, we will: (I) obtain smoking history data on 40,000 individuals (20,000 twin pairs) from an existing twin-family registry based in Virginia, North Carolina, and South Carolina to (II) identify 16,000 individuals who are lifetime regular smokers (-62 percent current, -28 percent past) and obtain a comprehensive baseline set of predictors and correlates of smoking cessation and relapse; and (III) follow the smoking status of these lifetime regular smokers prospectively at yearly intervals for three years to identify smoking cessation and relapse events. These efforts will yield complimentary prospective and retrospective data sets. Analysis of these data sets will allow us: to describe changes in smoking behavior over time; to identify the predictors of progression in readiness to change, persistent reduction in amount smoked, serious attempts at smoking cessation, successful smoking cessation, and smoking relapse; to use multivariate classification techniques to derive a typology applicable to individual smokers that identifies more homogeneous subgroups; to model the smoking process (i.e., smoking initiation-regular smoking-smoking cessation OR smoking initiation-cessation-relapse) to determine the magnitude and overlap of the genetic and environmental sources of variation in the processes; and to investigate the co-variation of the etiological genetic and environmental sources of variation in these processes with measures of personality, self-esteem, self-efficacy, and psychopathology. Accomplishing the aims of this proposal will advance significantly our knowledge of the determinants of smoking cessation and relapse The use of a twin design, a large/powerful sample, multivariate assessment of the key phenotypes, and advanced analytic methods are key components of our design and approach.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Special Emphasis Panel (ZRG1-SNEM-2 (01))
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Nayfield, Susan G
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Virginia Commonwealth University
Schools of Medicine
United States
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Svedberg, Pia; Mather, Lisa; Bergström, Gunnar et al. (2018) Work-Home Interference, Perceived Total Workload, and the Risk of Future Sickness Absence Due to Stress-Related Mental Diagnoses Among Women and Men: a Prospective Twin Study. Int J Behav Med 25:103-111
Thornton, Laura M; Welch, Elisabeth; Munn-Chernoff, Melissa A et al. (2016) Anorexia Nervosa, Major Depression, and Suicide Attempts: Shared Genetic Factors. Suicide Life Threat Behav 46:525-534
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Mather, Lisa; Bergström, Gunnar; Blom, Victoria et al. (2015) High Job Demands, Job Strain, and Iso-Strain are Risk Factors for Sick Leave due to Mental Disorders: A Prospective Swedish Twin Study With a 5-Year Follow-Up. J Occup Environ Med 57:858-65
Saha, Rama; Pettersson, Hans Järnbert; Svedberg, Pia et al. (2015) Heritability of endometriosis. Fertil Steril 104:947-952
Mather, Lisa; Bergström, Gunnar; Blom, Victoria et al. (2014) The covariation between burnout and sick leave due to mental disorders is explained by a shared genetic liability: a prospective swedish twin study with a five-year follow-up. Twin Res Hum Genet 17:535-44
Blom, Victoria; Sverke, Magnus; Bodin, Lennart et al. (2014) Work-home interference and burnout: a study based on Swedish twins. J Occup Environ Med 56:361-6
Mather, Lisa; Blom, Victoria; Svedberg, Pia (2014) Stressful and traumatic life events are associated with burnout-a cross-sectional twin study. Int J Behav Med 21:899-907
Algars, Monica; Huang, Lu; Von Holle, Ann F et al. (2014) Binge eating and menstrual dysfunction. J Psychosom Res 76:19-22
Trace, Sara E; Thornton, Laura M; Baker, Jessica H et al. (2013) A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder. Psychiatry Res 208:232-7

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