Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
9R01CA086379-08
Application #
6133572
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Mufson, R Allan
Project Start
2000-06-13
Project End
2005-04-30
Budget Start
2000-06-13
Budget End
2001-04-30
Support Year
8
Fiscal Year
2000
Total Cost
$385,598
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
David, Gregory; Grandinetti, Kathryn B; Finnerty, Patricia M et al. (2008) Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation. Proc Natl Acad Sci U S A 105:4168-72
David, G; Dannenberg, J-H; Simpson, N et al. (2006) Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. Oncogene 25:7354-60
Dannenberg, Jan-Hermen; David, Gregory; Zhong, Sheng et al. (2005) mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev 19:1581-95
Aguirre, Andrew J; Brennan, Cameron; Bailey, Gerald et al. (2004) High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A 101:9067-72
Li, Zhen; David, Gregory; Hung, Kwok-Wang et al. (2004) Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 279:54438-44
David, Gregory; Turner, Garth M; Yao, Yao et al. (2003) mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev 17:2396-405
David, Gregory; Neptune, Mychell A; DePinho, Ronald A (2002) SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem 277:23658-63
Castrillon, D H; DePinho, R A (2001) Modeling prostate cancer in the mouse. Adv Cancer Res 82:187-204