Studies in this grant period will focus on the hypothesis that chronic hypersecretion of LH, with a significant contribution from FSH, causes tumor formation by altering expression of a complex network of genes including a progressive down-regulation of the LH receptors and an increase in cyclin D2. The investigators will also map and clone the three non-allelic variants in the CF-1 genome necessary for GC tumorigenesis and contribute to its complete penetrance. In identifying gene expression profiles unique to the formation of granulosa cell tumors, these studies should contribute to a better understanding of permissive and causative events that underlie tumor formation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA086387-08
Application #
6706958
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Mietz, Judy
Project Start
2001-02-15
Project End
2006-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
8
Fiscal Year
2004
Total Cost
$297,270
Indirect Cost
Name
Washington State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
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