Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA094006-02
Application #
6692651
Study Section
Biochemistry Study Section (BIO)
Program Officer
Knowlton, John R
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$290,541
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Lone, Samer; Townson, Sharon A; Uljon, Sacha N et al. (2007) Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell 25:601-14
Johnson, Robert E; Prakash, Louise; Prakash, Satya (2006) Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization. Methods Enzymol 408:390-407
Johnson, Robert E; Prakash, Louise; Prakash, Satya (2005) Distinct mechanisms of cis-syn thymine dimer bypass by Dpo4 and DNA polymerase eta. Proc Natl Acad Sci U S A 102:12359-64
Gazdoiu, Stefan; Yamoah, Kosj; Wu, Kenneth et al. (2005) Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A 102:15053-8
Prakash, Satya; Johnson, Robert E; Prakash, Louise (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74:317-53
Trincao, Jose; Johnson, Robert E; Wolfle, William T et al. (2004) Dpo4 is hindered in extending a G.T mismatch by a reverse wobble. Nat Struct Mol Biol 11:457-62
Uljon, Sacha N; Johnson, Robert E; Edwards, Thomas A et al. (2004) Crystal structure of the catalytic core of human DNA polymerase kappa. Structure 12:1395-404
Johnson, Robert E; Trincao, Jose; Aggarwal, Aneel K et al. (2003) Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases. Mol Cell Biol 23:3008-12
Coia, L R; Minsky, B D; John, M J et al. (1999) The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus: results of the 1992-1994 Patterns of Care Study. Cancer 85:2499-505