Control of Tumor Growth by the MMP/Angiostatin Pathway

Pozzi, Ambra

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 3R01CA094849-01A1S1
• Application #: 6780662
• Study Section: Pathology B Study Section (PTHB)
• Program Officer: Rosenfeld, Bobby
• Project Start: 2003-01-10
• Project End: 2007-12-31
• Budget Start: 2003-07-01
• Budget End: 2003-12-31
• Support Year: 1
• Fiscal Year: 2003
• Total Cost: $27,331

Institution

• Name: Vanderbilt University Medical Center
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 004413456
• City: Nashville
• State: TN
• Country: United States
• Zip Code: 37212

Publications

Zhang, Ming-Zhi; Xu, Jie; Yao, Bing et al. (2009) Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest 119:876-85

Yang, Shiling; Wei, Shouzou; Pozzi, Ambra et al. (2009) The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Arch Biochem Biophys 489:82-91

Cosgrove, Dominic; Meehan, Daniel T; Delimont, Duane et al. (2008) Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Am J Pathol 172:761-73

Borza, Corina M; Borza, Dorin-Bogdan; Pedchenko, Vadim et al. (2008) Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol 19:677-84

Macias-Perez, Ines; Borza, Corina; Chen, Xiwu et al. (2008) Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res 68:6127-35

Erdogan, Mete; Pozzi, Ambra; Bhowmick, Neil et al. (2008) Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res 68:6224-31

Abair, Tristin D; Bulus, Nada; Borza, Corina et al. (2008) Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood 112:3242-54

Macias-Perez, Ines M; Zent, Roy; Carmosino, Monica et al. (2008) Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem 283:12538-45

Pozzi, Ambra; Jarad, George; Moeckel, Gilbert W et al. (2008) Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol 316:288-301

Chen, Xiwu; Abair, Tristin D; Ibanez, Maria R et al. (2007) Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol 27:3313-26