Inhibition of the TNF Apoptotic Pathway by HPV 16 E6

Duerksen-Hughes, Penelope J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 3R01CA095461-01A2S1
• Application #: 6911333
• Study Section: Virology Study Section (VR)
• Program Officer: Read-Connole, Elizabeth Lee
• Project Start: 2003-09-01
• Project End: 2008-08-31
• Budget Start: 2004-07-01
• Budget End: 2004-08-31
• Support Year: 1
• Fiscal Year: 2004
• Total Cost: $21,851

Institution

• Name: Loma Linda University
• Department: Other Basic Sciences
• Type: Schools of Medicine
• DUNS #: 009656273
• City: Loma Linda
• State: CA
• Country: United States
• Zip Code: 92350

Publications

Filippova, Maria; Evans, Whitney; Aragon, Robert et al. (2014) The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts. Virology 450-451:153-164

Williams, Vonetta M; Filippova, Maria; Filippov, Valery et al. (2014) Human papillomavirus type 16 E6* induces oxidative stress and DNA damage. J Virol 88:6751-61

Yuan, Chung-Hsiang; Filippova, Maria; Tungteakkhun, Sandy S et al. (2012) Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. Bioorg Med Chem Lett 22:2125-9

Haynes, Teka-Ann S; Filippov, Valery; Filippova, Maria et al. (2012) DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. Biochim Biophys Acta 1821:943-53

Whitaker, Erin L; Filippov, Valery; Filippova, Maria et al. (2011) Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. Cytokine 56:272-81

Williams, Vonetta M; Filippova, Maria; Soto, Ubaldo et al. (2011) HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virol 6:45-57

Tungteakkhun, Sandy S; Filippova, Maria; Fodor, Nadja et al. (2010) The full-length isoform of human papillomavirus 16 E6 and its splice variant E6* bind to different sites on the procaspase 8 death effector domain. J Virol 84:1453-63

Filippova, Maria; Filippov, Valery A; Kagoda, Mercy et al. (2009) Complexes of human papillomavirus type 16 E6 proteins form pseudo-death-inducing signaling complex structures during tumor necrosis factor-mediated apoptosis. J Virol 83:210-27

Tungteakkhun, Sandy S; Filippova, Maria; Neidigh, Jonathan W et al. (2008) The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain. J Virol 82:9600-14

Filippov, Valery; Schmidt, Erin L; Filippova, Maria et al. (2008) Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes. Gene 420:34-41