Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA095644-02
Application #
6694051
Study Section
Pathology B Study Section (PTHB)
Program Officer
Perry, Mary Ellen
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$260,871
Indirect Cost

  Institution

Name
University of Virginia
Department
Biochemistry
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Ramsey, C S; Yeung, F; Stoddard, P B et al. (2008) Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene 27:3516-26
Wang, Jialiang; An, Hanbing; Mayo, Marty W et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12:239-51
Hoberg, Jamie E; Popko, Anita E; Ramsey, Catherine S et al. (2006) IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26:457-71
Burstein, Ezra; Hoberg, Jamie E; Wilkinson, Amanda S et al. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem 280:22222-32
Denlinger, Chadrick E; Keller, Michael D; Mayo, Marty W et al. (2004) Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer. J Thorac Cardiovasc Surg 127:1078-86
Hoberg, Jamie E; Yeung, Fan; Mayo, Marty W (2004) SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell 16:245-55
Yeung, Fan; Hoberg, Jamie E; Ramsey, Catherine S et al. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23:2369-80
Mayo, Marty W; Denlinger, Chadrick E; Broad, Robert M et al. (2003) Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. J Biol Chem 278:18980-9