Abstract

Principal Investigator/Program Director (Last, first, middle): Chinnaiyan, Arul, M. Abstract: Our group has been involved in the molecular profiling of prostate cancer to identify novel clinical biomarkers, candidate regulatory genes, and therapeutic targets. One of the

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA097063-05S1
Application #
7487180
Study Section
Pathology B Study Section (PTHB)
Program Officer
Mohla, Suresh
Project Start
2002-07-01
Project End
2008-02-29
Budget Start
2007-07-01
Budget End
2008-02-29
Support Year
5
Fiscal Year
2007
Total Cost
$75,988
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Han, Bo; Mehra, Rohit; Dhanasekaran, Saravana M et al. (2008) A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer. Cancer Res 68:7629-37
Cao, Q; Yu, J; Dhanasekaran, S M et al. (2008) Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 27:7274-84
Yu, Jianjun; Yu, Jindan; Cordero, Kevin E et al. (2008) A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival. Neoplasia 10:79-88
Yu, Jianjun; Yu, Jindan; Almal, Arpit A et al. (2007) Feature selection and molecular classification of cancer using genetic programming. Neoplasia 9:292-303
Kim, Jung H; Dhanasekaran, Saravana M; Mehra, Rohit et al. (2007) Integrative analysis of genomic aberrations associated with prostate cancer progression. Cancer Res 67:8229-39
Yu, Jindan; Yu, Jianjun; Rhodes, Daniel R et al. (2007) A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res 67:10657-63
Yu, Jindan; Cao, Qi; Mehra, Rohit et al. (2007) Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 12:419-31
Loberg, Robert D; Bradley, Deborah A; Tomlins, Scott A et al. (2007) The lethal phenotype of cancer: the molecular basis of death due to malignancy. CA Cancer J Clin 57:225-41
Bismar, Tarek A; Demichelis, Francesca; Riva, Alberto et al. (2006) Defining aggressive prostate cancer using a 12-gene model. Neoplasia 8:59-68
Tomlins, Scott A; Mehra, Rohit; Rhodes, Daniel R et al. (2006) TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 66:3396-400

Showing the most recent 10 out of 29 publications