Environmental and genetic factors play a role in the development of colorectal cancer. Heterocyclic aromatic amines (HAAs) in high-temperature cooked meat and cigarette smoke are potential human colorectal carcinogens. HAAs need to be metabolically activated before they exert their carcinogenic effects. Several enzymes that are encoded by cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2 (NAT2) and possibly NAT1 are involved in this HAA activating pathway. Tea polyphenols are found to inhibit the formation of HAA adducts in animals, and therefore, may protect against the development of colorectal cancer in humans. The proposed study will utilize two established residential cohorts of Chinese to study the effects of dietary and non-dietary HAAs and green tea consumption on the risk of colorectal cancer. The Shanghai Cohort Study enrolled 18,244 men aged 45-64 years in Shanghai, China, during 1986-89. The Singapore Chinese Health Study enrolled 27,959 men and 35,298 women aged 45-74 years during 1993-1998. At recruitment, all cohort members provided detailed dietary and medical histories. Blood and urine specimens were collected from all Shanghai cohort members and about 50% of Singapore cohort members. The cohorts have been followed for the occurrence of cancer and death through routine ascertainment of new cases from the population-based Shanghai and Singapore cancer registries and vital statistical databases, and for the Shanghai Cohort Study, annual visits to all known surviving cohort members. To date, the cohorts have accumulated more than 680,000 person-years of observation. Among cohort members, 8,255 subjects have died and 5,735 have developed cancer, including 793 colorectal cancers. During the next 5 years, study investigators will assess the roles of dietary HAAs and tea polyphenol in the development of colorectal cancer using validated biomarker assays. The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA098497-02
Application #
6876070
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Hartmuller, Virginia W
Project Start
2004-04-01
Project End
2005-08-31
Budget Start
2005-04-18
Budget End
2005-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$34,183
Indirect Cost
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Odegaard, Andrew O; Koh, Woon-Puay; Yuan, Jian-Min et al. (2015) Beverage habits and mortality in Chinese adults. J Nutr 145:595-604
Koh, Angela S; Pan, An; Wang, Renwei et al. (2015) The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. Eur J Prev Cardiol 22:364-72
Talaei, Mohammad; Koh, Woon-Puay; van Dam, Rob M et al. (2014) Dietary soy intake is not associated with risk of cardiovascular disease mortality in Singapore Chinese adults. J Nutr 144:921-8
Odegaard, Andrew O; Koh, Woon-Puay; Yuan, Jian-Min et al. (2014) Dietary patterns and mortality in a Chinese population. Am J Clin Nutr 100:877-83
Untawale, Seema; Odegaard, Andrew O; Koh, Woon-Puay et al. (2014) Body mass index and risk of pancreatic cancer in a Chinese population. PLoS One 9:e85149
Rebello, Salome A; Koh, Hiromi; Chen, Cynthia et al. (2014) Amount, type, and sources of carbohydrates in relation to ischemic heart disease mortality in a Chinese population: a prospective cohort study. Am J Clin Nutr 100:53-64
Odegaard, Andrew O; Koh, Woon-Puay; Yuan, Jian-Min (2013) Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population. Cancer Prev Res (Phila) 6:360-7
Mueller, Noel T; Koh, Woon-Puay; Odegaard, Andrew O et al. (2013) Asthma and the risk of type 2 diabetes in the Singapore Chinese Health Study. Diabetes Res Clin Pract 99:192-9
Mueller, N T; Mueller, N J; Odegaard, A O et al. (2013) Higher parity is associated with an increased risk of type-II diabetes in Chinese women: the Singapore Chinese Health Study. BJOG 120:1483-9
Mueller, Noel T; Odegaard, Andrew O; Gross, Myron D et al. (2012) Soy intake and risk of type 2 diabetes in Chinese Singaporeans [corrected]. Eur J Nutr 51:1033-40

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