Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA099179-02
Application #
6694413
Study Section
Special Emphasis Panel (ZRG1-CAMP (01))
Program Officer
Spalholz, Barbara A
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$317,396
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cheong, Heesun; Lindsten, Tullia; Wu, Junmin et al. (2011) Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci U S A 108:11121-6
Joo, Joung Hyuck; Dorsey, Frank C; Joshi, Aashish et al. (2011) Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 43:572-85
Cárdenas, César; Miller, Russell A; Smith, Ian et al. (2010) Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142:270-83
Wellen, Kathryn E; Thompson, Craig B (2010) Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell 40:323-32
Gruber, Joshua J; Zatechka, D Steven; Sabin, Leah R et al. (2009) Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138:328-39
Jacob, Dena A; Ray, Theresa; Bengston, C Lynn et al. (2008) The role of cell death in sexually dimorphic muscle development: male-specific muscles are retained in female bax/bak knockout mice. Dev Neurobiol 68:1303-14
Kundu, Mondira; Lindsten, Tullia; Yang, Chia-Ying et al. (2008) Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112:1493-502
Jones, Russell G; Bui, Thi; White, Carl et al. (2007) The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity 27:268-80