Dose distributions associated with advanced radiation treatments (e.g. intensity modulated radiation therapy, IMRT) typically exhibit complicated steep dose gradients that conform to irregular anatomical surfaces in three-dimensions (3D). Comprehensive verification is difficult to achieve with conventional dosimeters presenting an immediate and substantial problem. In short, rapid advances in the technology to deliver radiation treatments have not been paralleled by corresponding advances in the ability to verify these treatments. A potential solution has emerged in the form of 3D gel-dosimetry utilizing optical-computed-tomography (optical-CT). It is the long-term objective of this proposal to investigate, optimize and develop gel-dosimetry to a level where accuracy is comparable to that of other standard relative clinical dosimeters (e.g. ion-chambers at 3%) while maintaining the unique feature of high spatial resolution in 3D (Imm3 or better). Should this be possible, it would represent a key goal for radiation dosimetry, and could significantly improve and influence clinical practice. The proposal includes the development and use of a model to study the fundamentals of light transport through the gel and scanning system and the transfer of signal and noise to dose reconstruction. The model will also enable optimization of the system and provide a platform of knowledge to guide in the refinement of future gel dosimeters. Gel-dosimeters (polymer and radiochromic gels) will be characterized according to the physical factors affecting accuracy. Finally, an optical-CT gel-dosimetry system is constructed that is capable of high-resolution 3D dose measurement with accuracy consistent with other standard dosimeters. The utility, accuracy and feasibility of the finalized system will be demonstrated by application to dosimetric verification of advanced IMRT, radiosurgery and brachytherapy treatments in the clinic. Completion will result in a 3D dosimetry system capable of unprecedented comprehensive dosimetric verification, and applicability to the spectrum of modern radiation treatments, including IMRT, brachytherapy, radiosurgery and orthovoltage teletherapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA100835-01
Application #
6601429
Study Section
Radiation Study Section (RAD)
Program Officer
Deye, James
Project Start
2003-04-01
Project End
2003-12-17
Budget Start
2003-04-01
Budget End
2003-12-17
Support Year
1
Fiscal Year
2003
Total Cost
$213,750
Indirect Cost
Name
William Beaumont Hospital
Department
Type
DUNS #
076362110
City
Royal Oak
State
MI
Country
United States
Zip Code
48073
Chisholm, Kelsey; Miles, Devin; Rankine, Leith et al. (2015) Investigations into the feasibility of optical-CT 3D dosimetry with minimal use of refractively matched fluids. Med Phys 42:2607-14
Bache, Steven T; Juang, Titania; Belley, Matthew D et al. (2015) Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters. Med Phys 42:846-55
Jackson, Jake; Juang, Titania; Adamovics, John et al. (2015) An investigation of PRESAGE® 3D dosimetry for IMRT and VMAT radiation therapy treatment verification. Phys Med Biol 60:2217-30
Juang, Titania; Grant, Ryan; Adamovics, John et al. (2014) On the feasibility of comprehensive high-resolution 3D remote dosimetry. Med Phys 41:071706
Adamson, Justus; Yang, Yun; Juang, Titania et al. (2014) On the feasibility of polyurethane based 3D dosimeters with optical CT for dosimetric verification of low energy photon brachytherapy seeds. Med Phys 41:071705
Vidovic, A K; Juang, T; Meltsner, S et al. (2014) An investigation of a PRESAGE® in vivo dosimeter for brachytherapy. Phys Med Biol 59:3893-905
Klawikowski, Slade J; Yang, James N; Adamovics, John et al. (2014) PRESAGE 3D dosimetry accurately measures Gamma Knife output factors. Phys Med Biol 59:N211-20
Oldham, M; Newton, J; Rankine, L et al. (2013) How accurate is image guided radiation therapy (IGRT) delivered with a micro-irradiator? J Phys Conf Ser 444:12070
Juang, Titania; Das, Shiva; Adamovics, John et al. (2013) On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter. Int J Radiat Oncol Biol Phys 87:414-21
Norris, H; Thomas, A; Oldham, M (2013) Evaluation of a clinically intuitive quality assurance method. J Phys Conf Ser 444:12022

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