The overall goal of the research will be to build on our progress in creating an integrated system for ablation of prostatic tissue incorporated advanced designs for the ablation prostate tissue, and ultimately prostatic carcinoma, in a rapid, precise fashion under MRI guidance. Applicators will either be directly inserted into the prostate gland through the perineum (interstitial applicators) of through the urethra (transurethral). Several new designs for transurethral applicators, designed to maximize speed and precision of treatment will be designed and tested. A system to perform automated rotational and linear mechanical control of applicators during in vivo treatments will be constructed. Systems for preventing rectal injury, including a endorectal cooling system using circulating water, and procedures for providing acoustic blocking between the prostate and rectum will be further developed. Further enhancements to our successful system for MR temperature imaging (MRTI) will be achieved using a referenceless approach, 3 point Dixon, multiple readouts per TR, and phased array imaging to create an optimal real-time system for monitoring of ablation. The research plan envisages a heirarchical series of experiments, with initial development and testing of all the component technologies described above, to be followed by extensive in vivo studies of prostate ablation in a canine model. In these experiments, different applicators and protocols will be tested and compared for performance in performing rapid, controlled ablation. MRTI techniques will be tested in these trials as well, with correlative thermocouple monitoring to assess accuracy. Improved histologic analysis techniques for resected prostate glands and periprostatic tissues following treatments will allow accurate correlation of MRTI data and post-treatment MR images, and a chronic model of prostatic ablation (7 or more days) will be assessed. At the completion of this work, we plan to have completely defined an integrated system suitable for clinical ablation of prostatic tissue and prostate cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA111981-03
Application #
7162906
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Farahani, Keyvan
Project Start
2005-01-13
Project End
2008-05-07
Budget Start
2007-01-01
Budget End
2008-05-07
Support Year
3
Fiscal Year
2007
Total Cost
$435,720
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Plata, Juan C; Holbrook, Andrew B; Marx, Michael et al. (2015) A feasibility study on monitoring the evolution of apparent diffusion coefficient decrease during thermal ablation. Med Phys 42:5130-7
Salgaonkar, Vasant A; Diederich, Chris J (2015) Catheter-based ultrasound technology for image-guided thermal therapy: current technology and applications. Int J Hyperthermia 31:203-15
Salgaonkar, Vasant A; Prakash, Punit; Rieke, Viola et al. (2014) Model-based feasibility assessment and evaluation of prostate hyperthermia with a commercial MR-guided endorectal HIFU ablation array. Med Phys 41:033301
Qin, Lei; Schmidt, Ehud J; Tse, Zion Tsz Ho et al. (2013) Prospective motion correction using tracking coils. Magn Reson Med 69:749-59
Sommer, Graham; Pauly, Kim Butts; Holbrook, Andrew et al. (2013) Applicators for magnetic resonance-guided ultrasonic ablation of benign prostatic hyperplasia. Invest Radiol 48:387-94
Sommer, Graham; Bouley, Donna; Gill, Harcharan et al. (2013) Focal ablation of prostate cancer: four roles for magnetic resonance imaging guidance. Can J Urol 20:6672-81
Prakash, Punit; Salgaonkar, Vasant A; Diederich, Chris J (2013) Modelling of endoluminal and interstitial ultrasound hyperthermia and thermal ablation: applications for device design, feedback control and treatment planning. Int J Hyperthermia 29:296-307
Salgaonkar, Vasant A; Prakash, Punit; Diederich, Chris J (2012) Temperature superposition for fast computation of 3D temperature distributions during optimization and planning of interstitial ultrasound hyperthermia treatments. Int J Hyperthermia 28:235-49
Prakash, Punit; Diederich, Chris J (2012) Considerations for theoretical modelling of thermal ablation with catheter-based ultrasonic sources: implications for treatment planning, monitoring and control. Int J Hyperthermia 28:69-86
Chen, Jing; Watkins, Ron; Pauly, Kim Butts (2010) Optimization of encoding gradients for MR-ARFI. Magn Reson Med 63:1050-8

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