Novel Targeted Therapeutics for Cental Nervous System Malignancies

Ali-Osman, Francis

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA112519-03
• Application #: 7332207
• Study Section: Clinical Neuroimmunology and Brain Tumors Study Section (CNBT)
• Program Officer: Lees, Robert G
• Project Start: 2006-02-10
• Project End: 2010-12-31
• Budget Start: 2008-01-08
• Budget End: 2008-12-31
• Support Year: 3
• Fiscal Year: 2008
• Total Cost: $327,069

Institution

• Name: Duke University
• Department: Surgery
• Type: Schools of Medicine
• DUNS #: 044387793
• City: Durham
• State: NC
• Country: United States
• Zip Code: 27705

Publications

Okamura, Tatsunori; Antoun, Gamil; Keir, Stephen T et al. (2015) Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells. J Biol Chem 290:30866-78

Singh, Simendra; Okamura, Tatsunori; Ali-Osman, Francis (2010) Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKC? enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. Biochem Pharmacol 80:1343-55

Okamura, Tatsunori; Singh, Simendra; Buolamwini, John et al. (2009) Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. J Biol Chem 284:16979-89

Lo, Hui-Wen; Stephenson, Lisa; Cao, Xinyu et al. (2008) Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. Mol Cancer Res 6:843-50

Lo, Hui-Wen; Ali-Osman, Francis (2007) Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Curr Opin Pharmacol 7:367-74