We propose a 5-year interdisciplinary project to integrate our recent advances and to accelerate research in key areas of virtual patient models for computing radiation doses. The objective is to set the foundation for a paradigm shift in the United States and the rest of the world in the ways that organ doses are calculated for high-energy photon/electron/proton radiotherapy, X-ray/CT imaging, and radiation risk epidemiological studies. We have recently shown that organ dose data obtained using the existing stylized patient models differ remarkably from those from patient-specific anatomies defined by CT, MR and Visible Human images. Therefore, it hypothesized that a new paradigm based on a unified 3-D whole-body computational patient phantom framework, systematically developed from detailed anatomical images and integrated with the modern Monte Carlo simulation tools, can improve the quality of clinical patient care that relies on organ dose calculations. A team of distinguished researchers is assembled to achieve the following Specific Aims: 1) To create a standardized reference library of computational patient 3D/4D anatomical models for both male and female patients of various ages and body sizes. 2) To incorporate these whole-body computational phantoms with easy-to-use Monte Carlo computing tools for 3D/4D radiation transport simulations involving various radiation types for common and emerging therapeutic and diagnostic procedures. 3) To test the hypothesis, we will evaluate the degrees to which the improved anatomical models of patients and modern Monte Carlo simulation tools will impact on the organ dose values and the clinical outcomes. 4) To establish and maintain a national center of computational phantom resources and an internet-based dissemination channel. We develop two common cores in this multi-group effort: 1) A standardized reference library of computational phantoms, and 2) A collection of user-friendly image-processing algorithms and Monte Carlo radiation transport simulation tools. These two cores then support four parallel clinical projects. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA116743-01
Application #
6965287
Study Section
Special Emphasis Panel (ZRG1-SBIB-Q (50))
Program Officer
Deye, James
Project Start
2005-07-27
Project End
2008-05-31
Budget Start
2005-07-27
Budget End
2006-05-31
Support Year
1
Fiscal Year
2005
Total Cost
$702,407
Indirect Cost
Name
Rensselaer Polytechnic Institute
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
002430742
City
Troy
State
NY
Country
United States
Zip Code
12180
Wayson, Michael B; Bolch, Wesley E (2018) Individualized adjustments to reference phantom internal organ dosimetry-scaling factors given knowledge of patient external anatomy. Phys Med Biol 63:085007
Wayson, Michael B; Bolch, Wesley E (2018) Individualized adjustments to reference phantom internal organ dosimetry-scaling factors given knowledge of patient internal anatomy. Phys Med Biol 63:085006
O'Reilly, Shannon E; DeWeese, Lindsay S; Maynard, Matthew R et al. (2016) An image-based skeletal dosimetry model for the ICRP reference adult female-internal electron sources. Phys Med Biol 61:8794-8824
Ding, Aiping; Gao, Yiming; Liu, Haikuan et al. (2015) VirtualDose: a software for reporting organ doses from CT for adult and pediatric patients. Phys Med Biol 60:5601-25
Xu, X George (2014) An exponential growth of computational phantom research in radiation protection, imaging, and radiotherapy: a review of the fifty-year history. Phys Med Biol 59:R233-302
Rajon, Didier; Bolch, Wesley E; Howell, Roger W (2013) Survival of tumor and normal cells upon targeting with electron-emitting radionuclides. Med Phys 40:014101
Gu, Jianwei; Xu, X George; Caracappa, Peter F et al. (2013) Fetal doses to pregnant patients from CT with tube current modulation calculated using Monte Carlo simulations and realistic phantoms. Radiat Prot Dosimetry 155:64-72
Wayson, Michael; Lee, Choonsik; Sgouros, George et al. (2012) Internal photon and electron dosimetry of the newborn patient--a hybrid computational phantom study. Phys Med Biol 57:1433-57
Howell, Roger W; Rajon, Didier; Bolch, Wesley E (2012) Monte Carlo simulation of irradiation and killing in three-dimensional cell populations with lognormal cellular uptake of radioactivity. Int J Radiat Biol 88:115-22
Su, Lin; Han, Bin; Xu, X George (2012) Calculated organ equivalent doses for individuals in a sitting posture above a contaminated ground and a PET imaging room. Radiat Prot Dosimetry 148:439-43

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