Abstract

Approximately 87% of women who undergo treatment for breast cancer are expected to survive for 5 years or longer. However, long-term, prospective follow-up studies of arm morbidity and its impact on functional status, mood, and quality of life (QOL) in these women are extremely limited. In fact, the study proposed in this grant application will be the first prospective longitudinal study of arm morbidity and patient outcomes following breast cancer treatment that has baseline data on arm morbidity outcomes prior to breast cancer surgery. Women for this study will be recruited from an ongoing NCI funded study that is evaluating the prevalence, severity, and timing of occurrence of neuropathic pain following breast cancer surgery and the factors that predict the development of these symptoms. Women (n=590) in the current study are recruited prior to surgery and are followed for 12 months. In this study, we propose to continue to follow these women for and additional 3 to 4 years depending on the time of enrollment.
The specific aims of the proposed study are to: determine the prevalence, severity, and the timing of the lymphedema (LE); determine the prevalence and timing of occurrence of changes in shoulder mobility and changes in grip strength associated with LE; compare differences in anxiety, depressed mood, fatigue, sleep disturbance, functional status, and quality of life (QOL) in women who do and do not develop LE; and determine the factors that predict the development of LE. A secondary aim of this study is to begin to elucidate genetic markers for neuropathic pain and LE following breast cancer surgery. Findings from this prospective, longitudinal study will be used to identify women who are at high risk for arm morbidity and to guide the development of interventions for arm morbidity. Lay Summary: This study will determine what percentage of women develop LE after breast cancer surgery and the effects of LE on arm function. In addition, what places a woman at risk for LE will be evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA118658-03
Application #
7478792
Study Section
Special Emphasis Panel (ZRG1-HOP-D (02))
Program Officer
O'Mara, Ann M
Project Start
2006-09-01
Project End
2011-07-31
Budget Start
2008-09-05
Budget End
2009-07-31
Support Year
3
Fiscal Year
2008
Total Cost
$696,815
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Alexander, Kimberly; Conley, Yvette P; Levine, Jon D et al. (2018) Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer. J Pain Symptom Manage 55:334-350.e3
Mazor, Melissa; Cataldo, Janine K; Lee, Kathryn et al. (2018) Influence of Menopausal Status on the Symptom Experience of Women Before Breast Cancer Surgery. Cancer Nurs 41:265-278
Mazor, Melissa; Cataldo, Janine K; Lee, Kathryn et al. (2018) Differences in symptom clusters before and twelve months after breast cancer surgery. Eur J Oncol Nurs 32:63-72
Mazor, Melissa; Lee, Kathryn; Dhruva, Anand et al. (2018) Menopausal-Related Symptoms in Women One Year After Breast Cancer Surgery. J Pain Symptom Manage 55:1138-1151.e1
Stephens, Kimberly E; Levine, Jon D; Aouizerat, Bradley E et al. (2017) Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery. Cytokine 99:203-213
Smoot, Betty; Kober, Kord M; Paul, Steven M et al. (2017) Potassium Channel Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery. Nurs Res 66:85-94
Eshragh, Jasmine; Dhruva, Anand; Paul, Steven M et al. (2017) Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery. J Pain Symptom Manage 53:67-84.e7
Smoot, Betty; Cooper, Bruce A; Conley, Yvette et al. (2016) Differences in limb volume trajectories after breast cancer treatment. J Cancer Surviv 10:772-82
Kober, Kord M; Smoot, Betty; Paul, Steven M et al. (2016) Polymorphisms in Cytokine Genes Are Associated With Higher Levels of Fatigue and Lower Levels of Energy in Women After Breast Cancer Surgery. J Pain Symptom Manage 52:695-708.e4
Smoot, Betty; Paul, Steven M; Aouizerat, Bradley E et al. (2016) Predictors of Altered Upper Extremity Function During the First Year After Breast Cancer Treatment. Am J Phys Med Rehabil 95:639-55

Showing the most recent 10 out of 37 publications