Immune Mechanisms Breast cancer is the most common cancer in women. After completion of successful therapy, many behavioral symptoms persist with over 20% of breast cancer survivors reporting chronic insomnia of greater than 6 months duration that fulfils clinical diagnostic criteria with associated functional limitations, decreased quality of life, and possible effects on long-term survival. Behavioral interventions are highly efficacious in the treatment of insomnia and preferred over hypnotic medications when insomnia is chronic. However, insomnia studies conducted in cancer are scarce. The proposed research builds upon a program of study that has examined the efficacy of a mind-body intervention, Tai Chi Chih (TCC), on health outcomes including sleep impairments. Preliminary studies show that TCC, a slow moving meditation, contributes to improvements in subjective sleep quality, sleep amounts and sleep efficiency. We have further found that sleep, fatigue, and proinflammatory cytokine activity are reciprocally related and that TCC decreases proinflammatory cytokine levels. Thus, we further hypothesize that cytokine network is one physiological mechanism through which TCC carries its effects on sleep outcomes. In this randomized, controlled trial, 100 breast cancer survivors will be randomly assigned to TCC or sleep hygiene/education control (EC) over 16 weeks and followed for one year.
The aims of this project are to: 1) evaluate the effects of TCC vs. EC on objective and subjective measures of sleep continuity, fatigue, and health functioning in breast cancer survivors with chronic insomnia; 2) determine the effects of TCC vs. EC on measures of proinflammatory cytokine activity; 3) evaluate whether circulating levels of proinflammatory cytokines temporally correlate with measures of sleep continuity in breast cancer survivors with insomnia over the course of the treatment trial. This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA119159-02
Application #
7284265
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Mc Donald, Paige A
Project Start
2006-09-06
Project End
2011-07-31
Budget Start
2007-08-15
Budget End
2008-07-31
Support Year
2
Fiscal Year
2007
Total Cost
$438,472
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kruse, Jennifer L; Congdon, Eliza; Olmstead, Richard et al. (2018) Inflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression. J Clin Psychiatry 79:
Eisenberger, Naomi I; Moieni, Mona; Inagaki, Tristen K et al. (2017) In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior. Neuropsychopharmacology 42:242-253
Bjurström, Martin F; Olmstead, Richard; Irwin, Michael R (2017) Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis. Psychosom Med 79:24-33
Irwin, Michael R; Opp, Mark R (2017) Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology 42:129-155
Irwin, Michael R; Olmstead, Richard; Carrillo, Carmen et al. (2017) Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial. J Clin Oncol 35:2656-2665
Irwin, Michael R; Eisenberger, Naomi I (2017) Context-Dependent Effects of Inflammation: Reduced Reward Responding is Not an Invariant Outcome of Sickness. Neuropsychopharmacology 42:785-786
Chiang, Jessica J; Tsai, Kim M; Park, Heejung et al. (2016) Daily family stress and HPA axis functioning during adolescence: The moderating role of sleep. Psychoneuroendocrinology 71:43-53
Bower, Julienne E; Irwin, Michael R (2016) Mind-body therapies and control of inflammatory biology: A descriptive review. Brain Behav Immun 51:1-11
Muscatell, Keely A; Moieni, Mona; Inagaki, Tristen K et al. (2016) Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback. Brain Behav Immun 57:21-29
Inagaki, Tristen K; Ray, Lara A; Irwin, Michael R et al. (2016) Opioids and social bonding: naltrexone reduces feelings of social connection. Soc Cogn Affect Neurosci 11:728-35

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