Use of assisted reproductive technology (ART) has risen steadily in the United States during the past two decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage. Studies have reported significantly higher risks of adverse perinatal outcomes in assisted- versus spontaneous-conception pregnancies, including an excess of prematurity, low birthweight, and birth defects. ART and/or infertility may influence the incidence of other conditions with prenatal origins, such as childhood cancer. In addition, the prevalence of imprinting disorders such as Beckwith-Wiedemann and Angelman syndromes is elevated among children conceived by ART;some of these disorders, in turn, drastically raise the risk of several embryonal cancers that occur in early childhood. Several cohort, case-control, and case- series studies of assisted reproduction and childhood cancer have reported null results, although all were limited by small sample size and could not differentiate specific cancer types. One study that focused specifically on hepatoblastoma found that use of infertility treatment or assisted reproduction was associated with a nine-fold increased risk of disease. Using the resources of the Society for Assisted Reproductive Technology (SART) and the birth and cancer registries in 20 States and New York City, we propose to conduct the largest study to date of ART and childhood cancer risk. SART maintains an ongoing national database of programs that provide ART services in the United States as mandated by the federal Fertility Success Rate and Certification Act of 1992 [PL 102-493]. As of 2006, the latest year of data available, this included comprehensive data (including identifiers sufficient for linkage) on 138,198 ART cycles from 483 clinics resulting in 41,343 pregnancies and 54,656 infants for a single year. We propose to link the data from the SART database from 2004-2013 to the birth and cancer registries of 20 states and New York City, including the five states with the highest numbers of ART births (California, New York, Illinois, New Jersey, and Massachusetts), to create a cohort of approximately 30 million children, including over 467,000 conceived by ART to evaluate the association between assisted reproduction and the risk for childhood cancer.
The specific aim of this study is to compare the incidence of childhood cancer in children with assisted conception to that in the general population.

Public Health Relevance

In this study we propose to link the data from the Society for Assisted Reproductive Technology national database from 2004-2013 to the birth and cancer registries of 19 states and New York City, to create a cohort of approximately 30 million children, including over 467,000 conceived by ART to evaluate the association between assisted reproduction and the risk for childhood cancer.
The specific aim of this study is to compare the incidence of childhood cancer in children with assisted conception to that in the general population.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA151973-01A1
Application #
8106700
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Shelburne, Nonniekaye F
Project Start
2011-03-01
Project End
2016-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
1
Fiscal Year
2011
Total Cost
$637,454
Indirect Cost
Name
Michigan State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Luke, Barbara; Brown, Morton B; Wantman, Ethan et al. (2018) Risk of severe maternal morbidity by maternal fertility status: a US study in 8 states. Am J Obstet Gynecol :
Luke, Barbara; Brown, Morton B; Spector, Logan G (2016) Validation of infertility treatment and assisted reproductive technology use on the birth certificate in eight states. Am J Obstet Gynecol 215:126-7
Luke, Barbara; Brown, Morton B; Spector, Logan G et al. (2016) Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois. J Assist Reprod Genet 33:667-674
Luke, Barbara; Brown, Morton B; Missmer, Stacey A et al. (2016) Assisted reproductive technology use and outcomes among women with a history of cancer. Hum Reprod 31:183-9
Luke, Barbara; Brown, Morton B; Spector, Logan G et al. (2015) Cancer in women after assisted reproductive technology. Fertil Steril 104:1218-26
Buck Louis, Germaine M; Druschel, Charlotte; Bell, Erin et al. (2015) Use of assisted reproductive technology treatment as reported by mothers in comparison with registry data: the Upstate KIDS Study. Fertil Steril 103:1461-8
Luke, Barbara; Brown, Morton B; Wantman, Ethan et al. (2015) Application of a validated prediction model for in vitro fertilization: comparison of live birth rates and multiple birth rates with 1 embryo transferred over 2 cycles vs 2 embryos in 1 cycle. Am J Obstet Gynecol 212:676.e1-7
Luke, Barbara; Brown, Morton B; Wantman, Ethan et al. (2014) A prediction model for live birth and multiple births within the first three cycles of assisted reproductive technology. Fertil Steril 102:744-52
Luke, Barbara; Brown, Morton B; Wantman, Ethan et al. (2014) Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles. Fertil Steril 101:683-9
Luke, Barbara; Brown, Morton B; Stern, Judy E et al. (2014) Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology. Fertil Steril 102:1338-44

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