The overall goal of this competing renewal application remains focused on developing and leveraging quantitative molecular imaging biomarkers that take advantage of a synergy between PET and MR imaging to provide significantly improved guidance for cancer radiation therapy (RT) in sarcomas. Traditionally, definition of the radiotherapy target volume utilizes CT and (sometimes) MR images to delineate visible gross tumor volume (GTV) which is expanded by certain margins to account for microscopic disease according to clinical guidelines, forming the clinical target volume (CTV). The standard T1/T2 weighted MR images are unable to distinguish tumor infiltration from inflammation and therefore inclusion of edema into the CTV is left to the physician's judgment. For patients unable to have resection, definitive RT results in local control of only 40 to 75% with the failures occurring primarily within the gross tumor. Standard anatomic imaging does not allow identification of areas at risk of local failure. We hypothesize that multiparametric PET/MR imaging will help to identify potential areas of resistant cell populations within the tumor in order to prescribe the higher dose to these areas to increase treatment effectiveness.

Public Health Relevance

Traditionally, definition of the radiotherapy target volume utilizes CT delineate visible gross tumor volume which is expanded by certain margins to account for microscopic disease. For patients unable to have resection, definitive radiotherapy results in local control of only 40 to 75%. We hypothesize that PET/MR imaging can help identify potential areas of resistant tumor, prescribe a higher dose to these areas and increase treatment effectiveness.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA165221-06A1
Application #
9748661
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Zhang, Huiming
Project Start
2012-05-01
Project End
2024-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
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