Abstract

This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.

Public Health Relevance

This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA178509-02
Application #
9063481
Study Section
Cancer Molecular Pathobiology Study Section (CAMP)
Program Officer
Ault, Grace S
Project Start
2015-05-05
Project End
2020-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

de la Parra, Columba; Walters, Beth A; Geter, Phillip et al. (2018) Translation initiation factors and their relevance in cancer. Curr Opin Genet Dev 48:82-88
Ernlund, Amanda W; Schneider, Robert J; Ruggles, Kelly V (2018) RIVET: comprehensive graphic user interface for analysis and exploration of genome-wide translatomics data. BMC Genomics 19:809
de la Parra, Columba; Ernlund, Amanda; Alard, Amandine et al. (2018) A widespread alternate form of cap-dependent mRNA translation initiation. Nat Commun 9:3068
Silvera, Deborah; Ernlund, Amanda; Arju, Rezina et al. (2017) mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells. Mol Cell Biol 37:
Suárez-Arroyo, Ivette J; Feliz-Mosquea, Yismeilin R; Pérez-Laspiur, Juliana et al. (2016) The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease. Am J Cancer Res 6:1720-40
Jhaveri, Komal; Teplinsky, Eleonora; Silvera, Deborah et al. (2016) Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy. Clin Breast Cancer 16:113-22.e1
Musa, Fernanda; Alard, Amandine; David-West, Gizelka et al. (2016) Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer. Mol Cancer Ther 15:1557-67