There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.
The proposed work will result in computational models for design and testing of novel nanoparticles that deliver high amounts of chemotherapy to target areas. This project will aid the in design of advanced nanoparticle drug carriers that reduce side effects of current chemotherapies while improving drug delivery to tumors.
|Burke, Caitlin; Dreher, Matthew R; Negussie, Ayele H et al. (2018) Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device. Int J Hyperthermia 34:786-794|
|Asemani, Davud; Haemmerich, Dieter (2018) A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors. IEEE Trans Nanobioscience 17:3-11|
|Bredlau, Amy Lee; Motamarry, Anjan; Chen, Chao et al. (2018) Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. Drug Deliv 25:973-984|
|Zalba, Sara; Ten Hagen, Timo L M (2017) Cell membrane modulation as adjuvant in cancer therapy. Cancer Treat Rev 52:48-57|
|Rossmann, Christian; McCrackin, M A; Armeson, Kent E et al. (2017) Temperature sensitive liposomes combined with thermal ablation: Effects of duration and timing of heating in mathematical models and in vivo. PLoS One 12:e0179131|
|Mikhail, Andrew S; Negussie, Ayele H; Pritchard, William F et al. (2017) Lyso-thermosensitive liposomal doxorubicin for treatment of bladder cancer. Int J Hyperthermia 33:733-740|
|Deshazer, Garron; Prakash, Punit; Merck, Derek et al. (2017) Experimental measurement of microwave ablation heating pattern and comparison to computer simulations. Int J Hyperthermia 33:74-82|
|Bredlau, A L; McCrackin, M A; Motamarry, Anjan et al. (2016) Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans. Crit Rev Biomed Eng 44:443-457|
|Swenson, Christine E; Haemmerich, Dieter; Maul, Donald H et al. (2015) Increased Duration of Heating Boosts Local Drug Deposition during Radiofrequency Ablation in Combination with Thermally Sensitive Liposomes (ThermoDox) in a Porcine Model. PLoS One 10:e0139752|
|Qi, Xiaoqiang; Li, Guangfu; Liu, Dai et al. (2015) Development of a radiofrequency ablation platform in a clinically relevant murine model of hepatocellular cancer. Cancer Biol Ther 16:1812-9|
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