There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.

Public Health Relevance

The proposed work will result in computational models for design and testing of novel nanoparticles that deliver high amounts of chemotherapy to target areas. This project will aid the in design of advanced nanoparticle drug carriers that reduce side effects of current chemotherapies while improving drug delivery to tumors.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Special Emphasis Panel (ZRG1-SBIB-Z (58))
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Farahani, Keyvan
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Medical University of South Carolina
Schools of Medicine
United States
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Burke, Caitlin; Dreher, Matthew R; Negussie, Ayele H et al. (2018) Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device. Int J Hyperthermia 34:786-794
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