Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA187109-04S1
Application #
9480929
Study Section
Developmental Therapeutics Study Section (DT)
Program Officer
Lin, Alison J
Project Start
2014-08-06
Project End
2018-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Purwada, Alberto; Shah, Shivem B; Béguelin, Wendy et al. (2018) Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells. Biomaterials :
Dominguez, Pilar M; Ghamlouch, Hussein; Rosikiewicz, Wojciech et al. (2018) TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. Cancer Discov 8:1632-1653
Béguelin, Wendy; Rivas, Martín A; Calvo Fernández, María T et al. (2017) EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop. Nat Commun 8:877
Jiang, Yanwen; Ortega-Molina, Ana; Geng, Huimin et al. (2017) CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Cancer Discov 7:38-53
Oricchio, Elisa; Katanayeva, Natalya; Donaldson, Maria Christine et al. (2017) Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma. Sci Transl Med 9:
Cardenas, Mariano G; Oswald, Erin; Yu, Wenbo et al. (2017) The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target. Clin Cancer Res 23:885-893
Jiang, Yanwen; Dominguez, Pilar M; Melnick, Ari M (2016) The many layers of epigenetic dysfunction in B-cell lymphomas. Curr Opin Hematol 23:377-84
Bunting, Karen L; Soong, T David; Singh, Rajat et al. (2016) Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region. Immunity 45:497-512
Béguelin, Wendy; Teater, Matt; Gearhart, Micah D et al. (2016) EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Cancer Cell 30:197-213
LaFave, Lindsay M; Béguelin, Wendy; Koche, Richard et al. (2015) Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med 21:1344-9

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