Microwave tomographic imaging of the breast has successfully advanced to initial clinical testing for monitoring treatment response to breast cancer neoadjuvant chemotherapy. The Dartmouth microwave imaging team has performed over 500 breast exams in both diagnostic and therapy monitoring settings which have demonstrated that recovered images of the endogenous dielectric properties are highly specific to distinguishing tumor from normal tissue, and to following response to therapy. In initial therapy monitoring patient studies, results indicate that images acquired as early as 30 days after the start of treatment correlate well with pathological outcomes. In this project, the Dartmouth microwave imaging group will team with General Electric's (GE's) Global Research Center to further refine and optimize the current technology as an important step towards translating it into the clinic. Design modifications are conceived to advance the technology using best engineering practices and to prepare it for a two center imaging study. Because the current system utilizes a modest amount of measurement data and has the lowest computational requirements of any microwave tomographic system world-wide, the overall costs will remain low and system configuration simplicity will be preserved. Designing for a second site will require a significant level of additional rigor be applied to the current system to ensure that it an be operated reliably and efficiently at a remote site. Refinements will incorporate previously proven spatial prior techniques designed to isolate the dielectric property recovery in pre-determined zones - specifically in tumor, and fibroglandular and adipose tissues without unduly biasing the final images. In addition, multi-frequency imaging methods will be refined and added to increase the spectral content of the recovered data and subsequently to improve the specificity of the reconstruction process. Each of these innovations will be incorporated into the new compact and portable design where special attention has been paid to clinical workflow requirements.
Currently, patients undergoing breast cancer neoadjuvant chemotherapy are underserved by conventional imaging modalities for monitoring tumor progression because of high costs and limited access. Early stage clinical results show that microwave tomography is poised to meet this need because it has demonstrated excellent correlation with treatment trajectory even at early time points when the information would be most beneficial to clinicians. This academic industrial partnership will provide an excellent platform for optimizing and refining the current technology using engineering and manufacturing practices and deploying it in a two- site clinical study for a more significant evaluation.
| Boverman, Gregory; Davis, Cynthia E L; Geimer, Shireen D et al. (2018) Image Registration for Microwave Tomography of the Breast Using Priors From Nonsimultaneous Previous Magnetic Resonance Images. IEEE J Electromagn RF Microw Med Biol 2:2-9 |
| Rydholm, Tomas; Fhager, Andreas; Persson, Mikael et al. (2018) Effects of the Plastic of the Realistic GeePS-L2S-Breast Phantom. Diagnostics (Basel) 8: |
| Meaney, Paul M; Fox, Colleen J; Geimer, Shireen D et al. (2017) Electrical Characterization of Glycerin: Water Mixtures: Implications for Use as a Coupling Medium in Microwave Tomography. IEEE Trans Microw Theory Tech 65:1471-1478 |
| Salahuddin, Saqib; Porter, Emily; Meaney, Paul M et al. (2017) Effect of Logarithmic and Linear Frequency Scales on Parametric Modelling of Tissue Dielectric Data. Biomed Phys Eng Express 3: |
| Meaney, Paul M; Geimer, Shireen D; Paulsen, Keith D (2017) Two-step inversion with a logarithmic transformation for microwave breast imaging. Med Phys 44:4239-4251 |
| Golnabi, Amir H; Meaney, Paul M; Paulsen, Keith D (2016) 3D microwave tomography of the breast using prior anatomical information. Med Phys 43:1933 |
| Meaney, Paul M; Gregory, Andrew P; Seppälä, Jan et al. (2016) Open-Ended Coaxial Dielectric Probe Effective Penetration Depth Determination. IEEE Trans Microw Theory Tech 64:915-923 |
| Meaney, Paul M; Williams, Benjamin B; Geimer, Shireen D et al. (2015) A Coaxial Dielectric Probe Technique for Distinguishing Tooth Enamel from Dental Resin. Adv Biomed Eng Res 3:8-17 |
