Diffuse Large B-Cell Lymphoma (DLBCL) is the most common form of lymphoma, comprising nearly 30% of all lymphoma cases. DLBCL is both clinically and molecularly heterogeneous. While nearly half of the patients are cured with standard therapy, the majority of the remaining patients succumb to the disease. In this proposal, we develop several complementary approaches that allow us to connect the specific genetic mutations in lymphomas to their context-specific roles. We propose to define the association of individual alterations with outcome, while accounting for the genetic heterogeneity among tumors. We have previously identified GNA13 as a commonly mutated gene in germinal center derived lymphomas including a subset of DLBCLs. We further propose to define lymphoma-specific roles of GNA13, as well as other variants that will be identified with this larger sample cohort through in vitro and in vivo approaches.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA193655-02
Application #
9040901
Study Section
Cancer Genetics Study Section (CG)
Program Officer
Agrawal, Lokesh
Project Start
2015-04-01
Project End
2020-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Reddy, Anupama; Zhang, Jenny; Davis, Nicholas S et al. (2017) Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell 171:481-494.e15