Irreversible electroporation (IRE) is a powerful new ablation technology that overcomes many of the primary limitations of thermal ablation approaches. However, for accurate, early prediction of treatment response, follow-up imaging methods must permit in vivo discrimination of irreversibly electroporated tissues from adjacent inadequately treated, reversibly electroporated tissues. Our most recent studies have demonstrated that quantitative MRI methods can detect electroporation-induced alterations to the cell membrane in both tumor and normal tissues. We will develop a powerful new MRI-guided IRE approach permitting a) pre- procedural planning to predict IRE ablation volumes, b) intra-procedural monitoring of tissue response and c) early post-procedural identification of inadequately treated (reversibly electroporated) tissues. Our ultimate goal is to achieve complete treatment of targeted tumors while avoiding excessive damage to adjacent liver tissues. The proposed pre-clinical project will address the following Specific Aims in a well-established rabbit liver tumor model:
Specific Aim 1 : To develop pre-procedural planning techniques to more accurately predict IRE ablation volumes.
Specific Aim 2 : To develop intra-procedural imaging methods for immediate functional monitoring of tumor tissue response.
Specific Aim 3 : To develop post-procedural imaging methods for early identification of inadequately treated, reversibly electroporated tumor tissues.

Public Health Relevance

A highly promising, recently developed treatment for liver tumors involves the application of strong electrical pulses to treat the targeted lesions. However, current imaging methods for monitoring response are highly sub- optimal. Superior imaging methods will be necessary for early, accurate prediction of long-term outcomes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA196967-02
Application #
9096074
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Project Start
2015-07-01
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Ji, Yang; Zhang, Chuanshan; Huang, Zhe et al. (2018) Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis. Am J Transl Res 10:2949-2957
Sun, Chong; Wang, Bin; Li, Jianmin et al. (2018) Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis. Am J Transl Res 10:1852-1859
Wang, Xifu; Su, Zhanliang; Lyu, Tianchu et al. (2018) 18F-FDG PET Biomarkers Help Detect Early Metabolic Response to Irreversible Electroporation and Predict Therapeutic Outcomes in a Rat Liver Tumor Model. Radiology 287:137-145
Zhou, Xin; Li, Jing; Guo, Junli et al. (2018) Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction. Microbiome 6:66
Xiong, Xuanqi; Zhou, Zhengwei; Figini, Matteo et al. (2018) Multi-parameter evaluation of lumbar intervertebral disc degeneration using quantitative magnetic resonance imaging techniques. Am J Transl Res 10:444-454
Su, Zhanliang; Wang, Xifu; Zheng, Linfeng et al. (2018) MRI-guided interventional natural killer cell delivery for liver tumor treatment. Cancer Med 7:1860-1869
Wang, Bin; Sun, Chong; Wang, Sijia et al. (2018) Mouse dendritic cell migration in abdominal lymph nodes by intraperitoneal administration. Am J Transl Res 10:2859-2867
Cai, Wei; Dong, Yan; Tian, Lu et al. (2018) Predictive Value of Four-Dimensional Strain Echocardiography for Adverse Cardiovascular Outcomes in ST-Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention. Cardiology 139:255-264
Shang, Na; Figini, Matteo; Shangguan, Junjie et al. (2017) Dendritic cells based immunotherapy. Am J Cancer Res 7:2091-2102
Lyu, Tianchu; Wang, Xifu; Su, Zhanliang et al. (2017) Irreversible electroporation in primary and metastatic hepatic malignancies: A review. Medicine (Baltimore) 96:e6386

Showing the most recent 10 out of 32 publications