Abstract

Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable type of brain cancer that arises in children. Recently genomic studies unraveled that a subset of human DIPGs harbor activating mutations in ACVR1 and K27M H3.1 mutations. Here we will study the mechanisms by which ACVR1 mutations and K27M H3.1 mutations cooperate in brainstem gliomagenesis.

Public Health Relevance

This Research Project Grant (R01) award will support Dr. Becher to use mouse genetics to study the mechanisms by which ACVR1 mutations cooperate with the K27M H3.1 mutation to promote diffuse intrinsic pontine glioma (DIPG) pathogenesis. These in vitro and in vivo studies will provide a mechanistic foundation for the design of safe and effective therapies to treat this incurable brain cancer that arises in children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA197313-02
Application #
9460260
Study Section
Clinical Neuroimmunology and Brain Tumors Study Section (CNBT)
Program Officer
Mietz, Judy
Project Start
2016-08-05
Project End
2022-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
2
Fiscal Year
2016
Total Cost
$359,995
Indirect Cost
$131,245

  Institution

Name
Northwestern University at Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Hoeman, Christine; Shen, Chen; Becher, Oren J (2018) CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma. Front Oncol 8:191