Genetic counseling and testing typically starts with a family member who is affected with breast or ovarian cancer. If a pathogenic variant (PV) is identified in this `index patient,' then she is encouraged to communicate with her at-risk relatives. First- and second-degree relatives of this index patient are at 50% and 25% risk for carrying the same PV. Undergoing targeted genetic testing for this variant has enormous potential benefits - particularly for those who have not been affected with cancer. Women who inherit a PV in BRCA1/2 are at 55- 70% risk of developing breast cancer and 16-45% risk of developing ovarian cancer. Men who inherit a PV are at increased risk for prostate, breast and pancreatic cancer. Learning that one carries the PV identified in the family allows women to take definitive actions to reduce their cancer risk and allows men to participate in high- risk surveillance programs recommended for male BRCA1/2 carriers. Further, men and women who learn that they do not carry the familial PV, can avoid unnecessary risk reduction and screening interventions and reassure their offspring that they are not at risk for carrying the familial PV. Despite these clear benefits, uptake of genetic counseling is low and only 28-57% of first- and second-degree relatives undergo testing. This low rate of genetic counseling and testing occurs despite high rates of communication. However, the accuracy and quality of the information communicated is not clear and additional practical barriers to uptake are common. Surprisingly, there have been no trials designed to improve the rate of uptake in this population. This represents a missed opportunity to reduce morbidity, mortality and costs associated with a variety of cancers. Observational studies suggest that direct contact from the genetics provider including Web resources and clinical referral is associated with higher counseling and testing uptake. These findings along with the low uptake in current clinical practice underscore the need to improve the standard approach for identifying, educating and testing relatives from hereditary breast ovarian cancer families. In the proposed randomized controlled trial, we will test a combination intervention which provides Web-based pre-test education and streamlined telephone-based genetic counseling (W+T) to first- and second-degree relatives of individuals who have recently received a positive BRCA1/2 test result. We will recruit 426 first- and second-degree relatives who have a 25-50% chance of carrying a PV and randomize them to W+T vs. Usual Care (UC). We will conduct a baseline survey prior to randomization and then follow-up surveys at 1- and 6-months post randomization. Our primary outcomes are the uptake of genetic counseling and genetic testing. Secondary outcomes include psychosocial outcomes, number of mutations detected and uptake of preventive/surveillance behaviors. This study, which is guided by the Health Belief Model and the Informed Choice Model, will have practical clinical significance through the development and evaluation of an intervention designed for individuals at the highest level of risk, potentially yielding improved cancer outcomes.

Public Health Relevance

Individuals from families in which a BRCA1/2 pathogenic variant has been identified are at high risk for carrying the variant and can benefit from genetic counseling and targeted genetic testing. However, few individuals from these families pursue genetic counseling and testing on their own. We will test an intervention designed to increase the appropriate use of genetic counseling and targeted testing in this extremely high risk population.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA223606-01A1
Application #
9593211
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Breslau, Erica S
Project Start
2018-06-08
Project End
2023-05-31
Budget Start
2018-06-08
Budget End
2019-05-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Georgetown University
Department
Type
Organized Research Units
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057